FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021460051> ?p ?o ?g. }

• W2021460051 endingPage "17" @default.
• W2021460051 startingPage "3" @default.
• W2021460051 abstract "The development of the chamber angle was studied in the eyes of heterozygous Pax6lacZ/+ mutant mice (Nature 387 (1997) 406). Mutations in PAX6 cause aniridia, a condition that is frequently associated with glaucoma, a blinding disease that may be associated with chamber angle defects. Mesenchymal cells were seen in the chamber angle at P1–P5. In wild-type mice, these cells differentiated into typical trabecular meshwork (TM) cells next to Schlemm's canal. In Pax6lacZ/+ mice, TM cells remained undifferentiated and Schlemm's canal was absent. From P1 to P4, staining for β-galactosidase and immunoreactivity for Pax6 were observed in chamber angle mesenchyme, but were absent later. Cultured murine TM cells expressed Pax6. The defects in chamber angle and TM differentiation were associated with a wide spectrum of other anterior eye defects, which included various degrees of iris hypoplasia and corneal haze, isolated iridocorneal adhesions and atypical coloboma, and a vascularized cornea in all adult animals. A third of the animals showed Peters' anomaly including corneal opacity and iridocorneal adhesions. The separation of the lens from the cornea was incomplete, and epithelial layers of lens and cornea were continuous. Pax6 activity is directly required for differentiation of the chamber angle. Variations in phenotype of Pax6lacZ/+ mice appear not to involve direct dominant-negative or dose-dependent effects." @default.
• W2021460051 created "2016-06-24" @default.
• W2021460051 creator A5006167710 @default.
• W2021460051 creator A5025109274 @default.
• W2021460051 creator A5036439412 @default.
• W2021460051 creator A5064794855 @default.
• W2021460051 creator A5067065466 @default.
• W2021460051 creator A5072834822 @default.
• W2021460051 date "2002-10-01" @default.
• W2021460051 modified "2023-10-18" @default.
• W2021460051 title "Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities" @default.
• W2021460051 cites W1543583271 @default.
• W2021460051 cites W1820659610 @default.
• W2021460051 cites W1965630384 @default.
• W2021460051 cites W1965640054 @default.
• W2021460051 cites W1966339894 @default.
• W2021460051 cites W1971596285 @default.
• W2021460051 cites W1995147287 @default.
• W2021460051 cites W2004069864 @default.
• W2021460051 cites W2004836501 @default.
• W2021460051 cites W2008161333 @default.
• W2021460051 cites W2021278943 @default.
• W2021460051 cites W2023497062 @default.
• W2021460051 cites W2033090591 @default.
• W2021460051 cites W2033690523 @default.
• W2021460051 cites W2035621553 @default.
• W2021460051 cites W2043218606 @default.
• W2021460051 cites W2043837938 @default.
• W2021460051 cites W2046293109 @default.
• W2021460051 cites W2053729206 @default.
• W2021460051 cites W2056601076 @default.
• W2021460051 cites W2062729230 @default.
• W2021460051 cites W2075521237 @default.
• W2021460051 cites W2081562228 @default.
• W2021460051 cites W2090268833 @default.
• W2021460051 cites W2091858601 @default.
• W2021460051 cites W2092959991 @default.
• W2021460051 cites W2093516817 @default.
• W2021460051 cites W2094943813 @default.
• W2021460051 cites W2095886901 @default.
• W2021460051 cites W2104724636 @default.
• W2021460051 cites W2108177555 @default.
• W2021460051 cites W2109210857 @default.
• W2021460051 cites W2112718652 @default.
• W2021460051 cites W2116778410 @default.
• W2021460051 cites W2118793302 @default.
• W2021460051 cites W2126414770 @default.
• W2021460051 cites W2127482249 @default.
• W2021460051 cites W2135108302 @default.
• W2021460051 cites W2140572701 @default.
• W2021460051 cites W2154040587 @default.
• W2021460051 cites W2157214897 @default.
• W2021460051 cites W2161687343 @default.
• W2021460051 cites W2165786409 @default.
• W2021460051 cites W2171508208 @default.
• W2021460051 cites W2184436455 @default.
• W2021460051 cites W2186656606 @default.
• W2021460051 cites W2260658880 @default.
• W2021460051 cites W2326461799 @default.
• W2021460051 cites W4323238746 @default.
• W2021460051 doi "https://doi.org/10.1016/s0925-4773(02)00260-5" @default.
• W2021460051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12351165" @default.
• W2021460051 hasPublicationYear "2002" @default.
• W2021460051 type Work @default.
• W2021460051 sameAs 2021460051 @default.
• W2021460051 citedByCount "135" @default.
• W2021460051 countsByYear W20214600512012 @default.
• W2021460051 countsByYear W20214600512013 @default.
• W2021460051 countsByYear W20214600512014 @default.
• W2021460051 countsByYear W20214600512015 @default.
• W2021460051 countsByYear W20214600512016 @default.
• W2021460051 countsByYear W20214600512017 @default.
• W2021460051 countsByYear W20214600512018 @default.
• W2021460051 countsByYear W20214600512019 @default.
• W2021460051 countsByYear W20214600512020 @default.
• W2021460051 countsByYear W20214600512021 @default.
• W2021460051 countsByYear W20214600512022 @default.
• W2021460051 countsByYear W20214600512023 @default.
• W2021460051 crossrefType "journal-article" @default.
• W2021460051 hasAuthorship W2021460051A5006167710 @default.
• W2021460051 hasAuthorship W2021460051A5025109274 @default.
• W2021460051 hasAuthorship W2021460051A5036439412 @default.
• W2021460051 hasAuthorship W2021460051A5064794855 @default.
• W2021460051 hasAuthorship W2021460051A5067065466 @default.
• W2021460051 hasAuthorship W2021460051A5072834822 @default.
• W2021460051 hasConcept C104317684 @default.
• W2021460051 hasConcept C105702510 @default.
• W2021460051 hasConcept C118487528 @default.
• W2021460051 hasConcept C151730666 @default.
• W2021460051 hasConcept C15336307 @default.
• W2021460051 hasConcept C184297639 @default.
• W2021460051 hasConcept C2776608714 @default.
• W2021460051 hasConcept C2776882836 @default.
• W2021460051 hasConcept C2778527774 @default.
• W2021460051 hasConcept C2779503344 @default.
• W2021460051 hasConcept C2780892088 @default.
• W2021460051 hasConcept C2781121420 @default.
• W2021460051 hasConcept C38652104 @default.

• next