FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021468215> ?p ?o ?g. }

• W2021468215 endingPage "46" @default.
• W2021468215 startingPage "40" @default.
• W2021468215 abstract "Background Epidermal nerve densities are increased in patients with atopic dermatitis (AD), suggesting that it is partly responsible for the intense itching in the skin. Epidermal hyperinnervation in AD patients is decreased by ultraviolet (UV) phototherapy, although the underlying mechanisms are poorly understood. Interestingly, abnormal expression of axonal guidance molecules, such as nerve growth factor (NGF) and semaphorin 3A (Sema3A), is found in the epidermis of AD patients. Therefore, UV phototherapy may alter levels of axonal guidance molecule expression in atopic skin. Objective This study was performed to investigate whether epidermal Sema3A and NGF levels in AD are influenced by psoralen-UVA (PUVA) therapy. Methods Skin biopsies obtained from chronic AD patients before and after PUVA therapy were used. Both Sema3A and NGF in the skin were examined at mRNA and protein levels by quantitative RT-PCR and immunohistochemistry, respectively. Nerve fibers in the skin were stained with anti-PGP9.5 antibody, and the number of epidermal nerve fibers was counted. Results PUVA therapy decreased epidermal nerve densities in AD patients, concomitant with decreases in both visual analog scale (VAS) scores for pruritus and clinical severity scores. Increased fluorescence intensity of Sema3A and decreased fluorescence intensity of NGF were observed in the epidermis of PUVA-treated group. Moreover, Sema3A mRNA levels were upregulated in the PUVA-treated skins compared with untreated controls, while NGF mRNA levels in the skin were downregulated by the treatment. Conclusion PUVA therapy may reduce epidermal hyperinnervation of AD by normalization of abnormal Sema3A and NGF expression in the epidermis." @default.
• W2021468215 created "2016-06-24" @default.
• W2021468215 creator A5007357352 @default.
• W2021468215 creator A5027549492 @default.
• W2021468215 creator A5040549451 @default.
• W2021468215 creator A5040622220 @default.
• W2021468215 creator A5048504310 @default.
• W2021468215 date "2009-07-01" @default.
• W2021468215 modified "2023-10-17" @default.
• W2021468215 title "Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis" @default.
• W2021468215 cites W130210233 @default.
• W2021468215 cites W158646000 @default.
• W2021468215 cites W1966170746 @default.
• W2021468215 cites W1968971111 @default.
• W2021468215 cites W1973256550 @default.
• W2021468215 cites W1978967991 @default.
• W2021468215 cites W1979005579 @default.
• W2021468215 cites W1980251112 @default.
• W2021468215 cites W1980321884 @default.
• W2021468215 cites W1999366816 @default.
• W2021468215 cites W2012514045 @default.
• W2021468215 cites W2016979573 @default.
• W2021468215 cites W2017167146 @default.
• W2021468215 cites W2020903065 @default.
• W2021468215 cites W2028199453 @default.
• W2021468215 cites W2041511646 @default.
• W2021468215 cites W2041587083 @default.
• W2021468215 cites W2055510343 @default.
• W2021468215 cites W2056650370 @default.
• W2021468215 cites W2067523166 @default.
• W2021468215 cites W2068054411 @default.
• W2021468215 cites W2068987538 @default.
• W2021468215 cites W2070739743 @default.
• W2021468215 cites W2072653944 @default.
• W2021468215 cites W2078936926 @default.
• W2021468215 cites W2081741849 @default.
• W2021468215 cites W2088005098 @default.
• W2021468215 cites W2089640550 @default.
• W2021468215 cites W2092068315 @default.
• W2021468215 cites W2095005947 @default.
• W2021468215 cites W2097689646 @default.
• W2021468215 cites W2101425240 @default.
• W2021468215 cites W2104773372 @default.
• W2021468215 cites W2114106556 @default.
• W2021468215 cites W2121392603 @default.
• W2021468215 cites W2143138262 @default.
• W2021468215 cites W2149579981 @default.
• W2021468215 cites W2164830294 @default.
• W2021468215 cites W2165038698 @default.
• W2021468215 doi "https://doi.org/10.1016/j.jdermsci.2009.03.007" @default.
• W2021468215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19443185" @default.
• W2021468215 hasPublicationYear "2009" @default.
• W2021468215 type Work @default.
• W2021468215 sameAs 2021468215 @default.
• W2021468215 citedByCount "106" @default.
• W2021468215 countsByYear W20214682152012 @default.
• W2021468215 countsByYear W20214682152013 @default.
• W2021468215 countsByYear W20214682152014 @default.
• W2021468215 countsByYear W20214682152015 @default.
• W2021468215 countsByYear W20214682152016 @default.
• W2021468215 countsByYear W20214682152017 @default.
• W2021468215 countsByYear W20214682152018 @default.
• W2021468215 countsByYear W20214682152019 @default.
• W2021468215 countsByYear W20214682152020 @default.
• W2021468215 countsByYear W20214682152021 @default.
• W2021468215 countsByYear W20214682152022 @default.
• W2021468215 countsByYear W20214682152023 @default.
• W2021468215 crossrefType "journal-article" @default.
• W2021468215 hasAuthorship W2021468215A5007357352 @default.
• W2021468215 hasAuthorship W2021468215A5027549492 @default.
• W2021468215 hasAuthorship W2021468215A5040549451 @default.
• W2021468215 hasAuthorship W2021468215A5040622220 @default.
• W2021468215 hasAuthorship W2021468215A5048504310 @default.
• W2021468215 hasConcept C105702510 @default.
• W2021468215 hasConcept C126322002 @default.
• W2021468215 hasConcept C132538176 @default.
• W2021468215 hasConcept C134018914 @default.
• W2021468215 hasConcept C142724271 @default.
• W2021468215 hasConcept C16005928 @default.
• W2021468215 hasConcept C170493617 @default.
• W2021468215 hasConcept C204232928 @default.
• W2021468215 hasConcept C2776458125 @default.
• W2021468215 hasConcept C2776805952 @default.
• W2021468215 hasConcept C2778329239 @default.
• W2021468215 hasConcept C2778423431 @default.
• W2021468215 hasConcept C2779923671 @default.
• W2021468215 hasConcept C2780200183 @default.
• W2021468215 hasConcept C2780564577 @default.
• W2021468215 hasConcept C71924100 @default.
• W2021468215 hasConceptScore W2021468215C105702510 @default.
• W2021468215 hasConceptScore W2021468215C126322002 @default.
• W2021468215 hasConceptScore W2021468215C132538176 @default.
• W2021468215 hasConceptScore W2021468215C134018914 @default.
• W2021468215 hasConceptScore W2021468215C142724271 @default.
• W2021468215 hasConceptScore W2021468215C16005928 @default.
• W2021468215 hasConceptScore W2021468215C170493617 @default.
• W2021468215 hasConceptScore W2021468215C204232928 @default.
• W2021468215 hasConceptScore W2021468215C2776458125 @default.

• next