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- W2021471651 abstract "Tanovea® (first named GS-9219, then VDC-1101, generic name: rabacfosadine) is a pro-prodrug or “double” prodrug of PMEG [9-(2-phosphonylmethoxyethyl)guanine], which has been conditionally approved by the US FDA (Food and Drug Administration) for the treatment of lymphoma in dogs. Tanovea has been demonstrated to be effective against non-Hodgkin’s lymphoma (NHL) in dogs, as well as canine cutaneous T-cell lymphoma, spontaneous canine multiple myeloma, naïve canine multicentric lymphoma and relapsed canine B-cell lymphoma. As a double prodrug of PMEG, GS-9219 is first converted intracellularly by hydrolysis to cPr-PMEDAP, then deaminated to PMEG, which is then phosphorylated twice to its active metabolite PMEGpp, acting at the level of the cellular DNA polymerases." @default.
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- W2021471651 date "2011-04-01" @default.
- W2021471651 modified "2023-09-27" @default.
- W2021471651 title "Have we reached a turning point in the diagnosis and treatment of canine lymphoma?" @default.
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- W2021471651 doi "https://doi.org/10.1016/j.tvjl.2010.09.018" @default.
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