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- W2021471698 abstract "Candida albicans, an opportunistic fungal pathogen, can cause severe systemic infections in susceptible patient groups. Systemic candidiasis is mainly studied in the mouse intravenous challenge model, where progressive infection correlates with increased early renal chemokine levels. To develop a new in vitro assay to assess C. albicans virulence, which reflects the events occurring in the murine infection model, renal M-1 cortical collecting duct epithelial cells were evaluated as the early producers of cytokines in response to C. albicans. We show that renal epithelial cells respond only to live C. albicans cells capable of forming hyphae, producing chemokines KC and MIP-2, with levels correlating with epithelial cell damage. By assaying epithelial cell responses to strains of known virulence in the murine intravenous challenge model we demonstrate that renal epithelial cells can discriminate between virulent and attenuated strains. This simple, novel assay is a useful initial screen for altered virulence of C. albicans mutants or clinical isolates in vitro and provides an alternative to the mouse systemic infection model." @default.
- W2021471698 created "2016-06-24" @default.
- W2021471698 creator A5062165952 @default.
- W2021471698 creator A5088189848 @default.
- W2021471698 date "2013-11-13" @default.
- W2021471698 modified "2023-09-23" @default.
- W2021471698 title "A novel renal epithelial cell in vitro assay to assessCandida albicansvirulence" @default.
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- W2021471698 doi "https://doi.org/10.4161/viru.27046" @default.
- W2021471698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3956504" @default.
- W2021471698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24225657" @default.
- W2021471698 hasPublicationYear "2013" @default.
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