Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021475474> ?p ?o ?g. }
- W2021475474 endingPage "1126" @default.
- W2021475474 startingPage "1121" @default.
- W2021475474 abstract "<h3>Objective:</h3> To determine how the advent of extrapyramidal signs influences the progression of Alzheimer disease as measured by standard clinical measures. <h3>Design:</h3> We applied growth curve models to prospective data to characterize patients' cognitive and functional changes over time. To detect changes in disease course related to extrapyramidal signs, their onset was treated as a time-dependent covariate. <h3>Setting:</h3> Three research medical centers. <h3>Participants:</h3> Patients (n=217) with probable Alzheimer disease. <h3>Intervention:</h3> Patients were followed up semiannually for 5 years. <h3>Main Outcome Measures:</h3> Scores on the modified Mini-Mental State Examination and measures of basic and instrumental activities of daily living from the Blessed Dementia Rating Scale. <h3>Results:</h3> For basic and instrumental activities of daily living, disease course was more rapid once extrapyramidal signs developed. Decline in the modified Mini-Mental State Examination score was greater at the time the signs developed, but not at subsequent visits. <h3>Conclusions:</h3> The point at which extrapyramidal signs emerge is associated with measurable acceleration in the progression of Alzheimer disease. This may in part explain why extrapyramidal signs are associated with a poorer prognosis. The differential influence of extrapyramidal signs on cognitive and functional measures suggests that the pathological changes underlying these disease features may vary." @default.
- W2021475474 created "2016-06-24" @default.
- W2021475474 creator A5010928244 @default.
- W2021475474 creator A5013224142 @default.
- W2021475474 creator A5018068494 @default.
- W2021475474 creator A5023108032 @default.
- W2021475474 creator A5023514892 @default.
- W2021475474 creator A5026163738 @default.
- W2021475474 creator A5032025339 @default.
- W2021475474 creator A5039384247 @default.
- W2021475474 creator A5051746525 @default.
- W2021475474 creator A5072399797 @default.
- W2021475474 date "1996-11-01" @default.
- W2021475474 modified "2023-10-18" @default.
- W2021475474 title "Modeling the Influence of Extrapyramidal Signs on the Progression of Alzheimer Disease" @default.
- W2021475474 cites W149602454 @default.
- W2021475474 cites W1503181891 @default.
- W2021475474 cites W1847168837 @default.
- W2021475474 cites W1992070450 @default.
- W2021475474 cites W1994172268 @default.
- W2021475474 cites W1999343631 @default.
- W2021475474 cites W2001253835 @default.
- W2021475474 cites W2012535452 @default.
- W2021475474 cites W2016413750 @default.
- W2021475474 cites W2022480405 @default.
- W2021475474 cites W2028064682 @default.
- W2021475474 cites W2030500443 @default.
- W2021475474 cites W2034562813 @default.
- W2021475474 cites W2040753345 @default.
- W2021475474 cites W2050894461 @default.
- W2021475474 cites W2056790002 @default.
- W2021475474 cites W2056966839 @default.
- W2021475474 cites W2080379931 @default.
- W2021475474 cites W2081283200 @default.
- W2021475474 cites W2082572553 @default.
- W2021475474 cites W2104709900 @default.
- W2021475474 cites W2117657533 @default.
- W2021475474 cites W2120924264 @default.
- W2021475474 cites W2128136330 @default.
- W2021475474 cites W2136641879 @default.
- W2021475474 cites W2156220037 @default.
- W2021475474 cites W2159529587 @default.
- W2021475474 cites W2408722770 @default.
- W2021475474 cites W2923843952 @default.
- W2021475474 doi "https://doi.org/10.1001/archneur.1996.00550110061013" @default.
- W2021475474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8912485" @default.
- W2021475474 hasPublicationYear "1996" @default.
- W2021475474 type Work @default.
- W2021475474 sameAs 2021475474 @default.
- W2021475474 citedByCount "39" @default.
- W2021475474 countsByYear W20214754742013 @default.
- W2021475474 countsByYear W20214754742014 @default.
- W2021475474 countsByYear W20214754742016 @default.
- W2021475474 countsByYear W20214754742021 @default.
- W2021475474 countsByYear W20214754742022 @default.
- W2021475474 crossrefType "journal-article" @default.
- W2021475474 hasAuthorship W2021475474A5010928244 @default.
- W2021475474 hasAuthorship W2021475474A5013224142 @default.
- W2021475474 hasAuthorship W2021475474A5018068494 @default.
- W2021475474 hasAuthorship W2021475474A5023108032 @default.
- W2021475474 hasAuthorship W2021475474A5023514892 @default.
- W2021475474 hasAuthorship W2021475474A5026163738 @default.
- W2021475474 hasAuthorship W2021475474A5032025339 @default.
- W2021475474 hasAuthorship W2021475474A5039384247 @default.
- W2021475474 hasAuthorship W2021475474A5051746525 @default.
- W2021475474 hasAuthorship W2021475474A5072399797 @default.
- W2021475474 hasConcept C118552586 @default.
- W2021475474 hasConcept C126322002 @default.
- W2021475474 hasConcept C15744967 @default.
- W2021475474 hasConcept C2776412080 @default.
- W2021475474 hasConcept C2779077818 @default.
- W2021475474 hasConcept C2779134260 @default.
- W2021475474 hasConcept C2779483572 @default.
- W2021475474 hasConcept C2780494398 @default.
- W2021475474 hasConcept C2780616385 @default.
- W2021475474 hasConcept C2780906993 @default.
- W2021475474 hasConcept C502032728 @default.
- W2021475474 hasConcept C71924100 @default.
- W2021475474 hasConceptScore W2021475474C118552586 @default.
- W2021475474 hasConceptScore W2021475474C126322002 @default.
- W2021475474 hasConceptScore W2021475474C15744967 @default.
- W2021475474 hasConceptScore W2021475474C2776412080 @default.
- W2021475474 hasConceptScore W2021475474C2779077818 @default.
- W2021475474 hasConceptScore W2021475474C2779134260 @default.
- W2021475474 hasConceptScore W2021475474C2779483572 @default.
- W2021475474 hasConceptScore W2021475474C2780494398 @default.
- W2021475474 hasConceptScore W2021475474C2780616385 @default.
- W2021475474 hasConceptScore W2021475474C2780906993 @default.
- W2021475474 hasConceptScore W2021475474C502032728 @default.
- W2021475474 hasConceptScore W2021475474C71924100 @default.
- W2021475474 hasIssue "11" @default.
- W2021475474 hasLocation W20214754741 @default.
- W2021475474 hasLocation W20214754742 @default.
- W2021475474 hasOpenAccess W2021475474 @default.
- W2021475474 hasPrimaryLocation W20214754741 @default.
- W2021475474 hasRelatedWork W1985896582 @default.
- W2021475474 hasRelatedWork W2075528565 @default.
- W2021475474 hasRelatedWork W2079409065 @default.