FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021481489> ?p ?o ?g. }

• W2021481489 endingPage "e55228" @default.
• W2021481489 startingPage "e55228" @default.
• W2021481489 abstract "No licensed vaccine is currently available against serotype A foot-and-mouth disease (FMD) in China, despite the isolation of A/WH/CHA/09 in 2009, partly because this strain does not replicate well in baby hamster kidney (BHK) cells.A novel plasmid-based reverse genetics system was used to construct a chimeric strain by replacing the P1 gene in the vaccine strain O/CHA/99 with that from the epidemic stain A/WH/CHA/09. The chimeric virus displayed growth kinetics similar to those of O/CHA/99 and was selected for use as a candidate vaccine strain after 12 passages in BHK cells. Cattle were vaccinated with the inactivated vaccine and humoral immune responses were induced in most of the animals on day 7. A challenge infection with A/WH/CHA/09 on day 28 indicated that the group given a 4-µg dose was fully protected and neither developed viremia nor seroconverted to a 3ABC antigen.Our data demonstrate that the chimeric virus not only propagates well in BHK cells and has excellent antigenic matching against serotype A FMD, but is also a potential marker vaccine to distinguish infection from vaccination. These results suggest that reverse genetics technology is a useful tool for engineering vaccines for the prevention and control of FMD." @default.
• W2021481489 created "2016-06-24" @default.
• W2021481489 creator A5018056194 @default.
• W2021481489 creator A5019221209 @default.
• W2021481489 creator A5021676921 @default.
• W2021481489 creator A5026349233 @default.
• W2021481489 creator A5038048526 @default.
• W2021481489 creator A5042855183 @default.
• W2021481489 creator A5060017249 @default.
• W2021481489 creator A5069046123 @default.
• W2021481489 creator A5069861427 @default.
• W2021481489 creator A5081183372 @default.
• W2021481489 date "2013-01-25" @default.
• W2021481489 modified "2023-10-18" @default.
• W2021481489 title "Engineering Foot-and-Mouth Disease Viruses with Improved Growth Properties for Vaccine Development" @default.
• W2021481489 cites W1515340690 @default.
• W2021481489 cites W1664840542 @default.
• W2021481489 cites W1938043974 @default.
• W2021481489 cites W1963531806 @default.
• W2021481489 cites W1988724578 @default.
• W2021481489 cites W2004234629 @default.
• W2021481489 cites W2011891163 @default.
• W2021481489 cites W2027437986 @default.
• W2021481489 cites W2036277271 @default.
• W2021481489 cites W2037691295 @default.
• W2021481489 cites W2043624788 @default.
• W2021481489 cites W2044142648 @default.
• W2021481489 cites W2055561571 @default.
• W2021481489 cites W2056343886 @default.
• W2021481489 cites W2057185503 @default.
• W2021481489 cites W2061531851 @default.
• W2021481489 cites W2072892746 @default.
• W2021481489 cites W2073491191 @default.
• W2021481489 cites W2074471872 @default.
• W2021481489 cites W2078587242 @default.
• W2021481489 cites W2084487943 @default.
• W2021481489 cites W2097445077 @default.
• W2021481489 cites W2100701307 @default.
• W2021481489 cites W2122755078 @default.
• W2021481489 cites W2130808727 @default.
• W2021481489 cites W2136755538 @default.
• W2021481489 cites W2142656395 @default.
• W2021481489 cites W2146861964 @default.
• W2021481489 cites W2151920005 @default.
• W2021481489 cites W2158739893 @default.
• W2021481489 cites W2171347049 @default.
• W2021481489 cites W2616233624 @default.
• W2021481489 doi "https://doi.org/10.1371/journal.pone.0055228" @default.
• W2021481489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3555929" @default.
• W2021481489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23372840" @default.
• W2021481489 hasPublicationYear "2013" @default.
• W2021481489 type Work @default.
• W2021481489 sameAs 2021481489 @default.
• W2021481489 citedByCount "33" @default.
• W2021481489 countsByYear W20214814892014 @default.
• W2021481489 countsByYear W20214814892015 @default.
• W2021481489 countsByYear W20214814892016 @default.
• W2021481489 countsByYear W20214814892017 @default.
• W2021481489 countsByYear W20214814892018 @default.
• W2021481489 countsByYear W20214814892019 @default.
• W2021481489 countsByYear W20214814892020 @default.
• W2021481489 countsByYear W20214814892021 @default.
• W2021481489 countsByYear W20214814892022 @default.
• W2021481489 countsByYear W20214814892023 @default.
• W2021481489 crossrefType "journal-article" @default.
• W2021481489 hasAuthorship W2021481489A5018056194 @default.
• W2021481489 hasAuthorship W2021481489A5019221209 @default.
• W2021481489 hasAuthorship W2021481489A5021676921 @default.
• W2021481489 hasAuthorship W2021481489A5026349233 @default.
• W2021481489 hasAuthorship W2021481489A5038048526 @default.
• W2021481489 hasAuthorship W2021481489A5042855183 @default.
• W2021481489 hasAuthorship W2021481489A5060017249 @default.
• W2021481489 hasAuthorship W2021481489A5069046123 @default.
• W2021481489 hasAuthorship W2021481489A5069861427 @default.
• W2021481489 hasAuthorship W2021481489A5081183372 @default.
• W2021481489 hasBestOaLocation W20214814891 @default.
• W2021481489 hasConcept C10389963 @default.
• W2021481489 hasConcept C147483822 @default.
• W2021481489 hasConcept C159047783 @default.
• W2021481489 hasConcept C167508917 @default.
• W2021481489 hasConcept C203014093 @default.
• W2021481489 hasConcept C22070199 @default.
• W2021481489 hasConcept C2522874641 @default.
• W2021481489 hasConcept C2776151397 @default.
• W2021481489 hasConcept C2776185481 @default.
• W2021481489 hasConcept C2776872762 @default.
• W2021481489 hasConcept C2779070877 @default.
• W2021481489 hasConcept C2780801004 @default.
• W2021481489 hasConcept C33263850 @default.
• W2021481489 hasConcept C86803240 @default.
• W2021481489 hasConcept C8891405 @default.
• W2021481489 hasConceptScore W2021481489C10389963 @default.
• W2021481489 hasConceptScore W2021481489C147483822 @default.
• W2021481489 hasConceptScore W2021481489C159047783 @default.
• W2021481489 hasConceptScore W2021481489C167508917 @default.
• W2021481489 hasConceptScore W2021481489C203014093 @default.
• W2021481489 hasConceptScore W2021481489C22070199 @default.
• W2021481489 hasConceptScore W2021481489C2522874641 @default.

• next