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- W2021482392 abstract "We have developed a biophysical model of a cultured rat cerebellar granule neuron and simulated its excitability under different experimental conditions. The basic excitability properties of such a small neuron; the specific action potential waveforms, the overall firing patterns induced by current stimulations, and the linear frequency-current relation, are the main model constraints. Simulations show that for a one-compartmental granule neuron model, the constraints are met using six voltage- and time-dependent ion channel types and calcium dynamics linked to BKCa ion channel function. This kind of model of a single neuron forms a solid basis for building the increasingly more complex network models of cultured neurons, and specifically for the cerebellar neuronal network." @default.
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- W2021482392 date "2003-06-01" @default.
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- W2021482392 title "Simulations of the cultured granule neuron excitability" @default.
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- W2021482392 doi "https://doi.org/10.1016/s0925-2312(02)00804-4" @default.
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