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- W2021489122 abstract "Because of its lack of nephrotoxicity, the use of sirolimus, as an immunosuppressive agent, has increased considerably in solid-organ transplant (Tx) recipients. With its increased use, Tx professionals are encountering a variety of previously unreported side-effects such as angioedema and interstitial pneumonitis. We describe here the case of a pediatric renal Tx recipient who, while receiving sirolimus, developed a large pericardial effusion requiring pericardiocentesis. An extensive workup for an infectious etiology was performed; the only positive result was isolation of adenovirus type 2 from the patient's stool specimen. Following sirolimus dose reduction this child's effusion stabilized and has not recurred. The purpose of this report is to advise health-care professionals caring for Tx recipients about this potentially life-threatening complication associated with sirolimus. The role of adenovirus, if any, in contributing to the development of our patient's pericardial effusion is discussed herein." @default.
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- W2021489122 date "2005-07-27" @default.
- W2021489122 modified "2023-10-10" @default.
- W2021489122 title "Cardiac tamponade in a pediatric renal transplant recipient on sirolimus therapy" @default.
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- W2021489122 doi "https://doi.org/10.1111/j.1399-3046.2005.00323.x" @default.
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