FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021489239> ?p ?o ?g. }

• W2021489239 endingPage "386" @default.
• W2021489239 startingPage "377" @default.
• W2021489239 abstract "Nitric oxide (NO) attenuates α‐adrenergic vasoconstriction in contracting rodent skeletal muscle, but it is unclear if NO plays a similar role in human muscle. We therefore hypothesized that in humans, NO produced in exercising skeletal muscle blunts the vasoconstrictor response to sympathetic activation. We assessed vasoconstrictor responses in the microcirculation of human forearm muscle using near‐infrared spectroscopy to measure decreases in muscle oxygenation during reflex sympathetic activation evoked by lower body negative pressure (LBNP). Experiments were performed before and after NO synthase inhibition produced by systemic infusion of N G ‐nitro‐ l ‐arginine methyl ester ( l ‐NAME). Before l ‐NAME, LBNP at −20 mmHg decreased muscle oxygenation by 20 ± 2 % in resting forearm and by 2 ± 3 % in exercising forearm ( n = 20 ), demonstrating metabolic modulation of sympathetic vasoconstriction. As expected, l ‐NAME increased mean arterial pressure by 17 ± 3 mmHg, leading to baroreflex‐mediated supression of baseline muscle sympathetic nerve activity (SNA). The increment in muscle SNA in response to LBNP at −20 mmHg also was attenuated after l ‐NAME (before, +14 ± 2; after, +8 ± 1 bursts min −1 ; n = 6 ), but this effect of l ‐NAME was counteracted by increasing LBNP to −40 mmHg (+19 ± 2 bursts min −1 ). After l ‐NAME, LBNP at −20 mmHg decreased muscle oxygenation similarly in resting (−11 ± 3 %) and exercising (−10 ± 2 %) forearm ( n = 12 ). Likewise, LBNP at −40 mmHg decreased muscle oxygenation both in resting (−19 ± 4 %) and exercising (−21 ± 5 %) forearm ( n = 8 ). These data advance the hypothesis that NO plays an important role in modulating sympathetic vasoconstriction in the microcirculation of exercising muscle, because such modulation is abrogated by NO synthase inhibition with l ‐NAME." @default.
• W2021489239 created "2016-06-24" @default.
• W2021489239 creator A5005718724 @default.
• W2021489239 creator A5011058208 @default.
• W2021489239 creator A5011335360 @default.
• W2021489239 creator A5012379764 @default.
• W2021489239 creator A5016034469 @default.
• W2021489239 creator A5049663947 @default.
• W2021489239 date "2002-04-01" @default.
• W2021489239 modified "2023-10-15" @default.
• W2021489239 title "Nitric oxide‐dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle" @default.
• W2021489239 cites W1800235608 @default.
• W2021489239 cites W1837367668 @default.
• W2021489239 cites W1896419431 @default.
• W2021489239 cites W1914691075 @default.
• W2021489239 cites W1957992664 @default.
• W2021489239 cites W1969764912 @default.
• W2021489239 cites W1979675693 @default.
• W2021489239 cites W1993113186 @default.
• W2021489239 cites W1998784137 @default.
• W2021489239 cites W2010469212 @default.
• W2021489239 cites W2010917138 @default.
• W2021489239 cites W2011857875 @default.
• W2021489239 cites W2027221381 @default.
• W2021489239 cites W2029038770 @default.
• W2021489239 cites W2033676880 @default.
• W2021489239 cites W2036596655 @default.
• W2021489239 cites W2042054187 @default.
• W2021489239 cites W2049863374 @default.
• W2021489239 cites W2052928078 @default.
• W2021489239 cites W2054558538 @default.
• W2021489239 cites W2059155059 @default.
• W2021489239 cites W2086823174 @default.
• W2021489239 cites W2092928881 @default.
• W2021489239 cites W2096320400 @default.
• W2021489239 cites W2113769239 @default.
• W2021489239 cites W2129057166 @default.
• W2021489239 cites W2132580447 @default.
• W2021489239 cites W2148004339 @default.
• W2021489239 cites W2152928341 @default.
• W2021489239 cites W2172218838 @default.
• W2021489239 cites W2173187357 @default.
• W2021489239 cites W2176489849 @default.
• W2021489239 cites W2180338224 @default.
• W2021489239 cites W2243722387 @default.
• W2021489239 cites W2279182902 @default.
• W2021489239 cites W2279317831 @default.
• W2021489239 cites W2280189486 @default.
• W2021489239 cites W2311393071 @default.
• W2021489239 cites W2340972511 @default.
• W2021489239 cites W2395970043 @default.
• W2021489239 cites W2400097067 @default.
• W2021489239 cites W2746027690 @default.
• W2021489239 cites W600728777 @default.
• W2021489239 cites W61977801 @default.
• W2021489239 doi "https://doi.org/10.1113/jphysiol.2001.013153" @default.
• W2021489239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2290221" @default.
• W2021489239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11927694" @default.
• W2021489239 hasPublicationYear "2002" @default.
• W2021489239 type Work @default.
• W2021489239 sameAs 2021489239 @default.
• W2021489239 citedByCount "116" @default.
• W2021489239 countsByYear W20214892392012 @default.
• W2021489239 countsByYear W20214892392013 @default.
• W2021489239 countsByYear W20214892392014 @default.
• W2021489239 countsByYear W20214892392015 @default.
• W2021489239 countsByYear W20214892392016 @default.
• W2021489239 countsByYear W20214892392017 @default.
• W2021489239 countsByYear W20214892392018 @default.
• W2021489239 countsByYear W20214892392019 @default.
• W2021489239 countsByYear W20214892392020 @default.
• W2021489239 countsByYear W20214892392021 @default.
• W2021489239 countsByYear W20214892392022 @default.
• W2021489239 countsByYear W20214892392023 @default.
• W2021489239 crossrefType "journal-article" @default.
• W2021489239 hasAuthorship W2021489239A5005718724 @default.
• W2021489239 hasAuthorship W2021489239A5011058208 @default.
• W2021489239 hasAuthorship W2021489239A5011335360 @default.
• W2021489239 hasAuthorship W2021489239A5012379764 @default.
• W2021489239 hasAuthorship W2021489239A5016034469 @default.
• W2021489239 hasAuthorship W2021489239A5049663947 @default.
• W2021489239 hasBestOaLocation W20214892392 @default.
• W2021489239 hasConcept C105702510 @default.
• W2021489239 hasConcept C120770815 @default.
• W2021489239 hasConcept C126322002 @default.
• W2021489239 hasConcept C134018914 @default.
• W2021489239 hasConcept C164705383 @default.
• W2021489239 hasConcept C185592680 @default.
• W2021489239 hasConcept C191237925 @default.
• W2021489239 hasConcept C2777953023 @default.
• W2021489239 hasConcept C2779959927 @default.
• W2021489239 hasConcept C2779961880 @default.
• W2021489239 hasConcept C2780214079 @default.
• W2021489239 hasConcept C42219234 @default.
• W2021489239 hasConcept C519581460 @default.
• W2021489239 hasConcept C70289976 @default.
• W2021489239 hasConcept C71924100 @default.
• W2021489239 hasConcept C83974742 @default.

• next