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- W2021491719 abstract "Gastric mucosa-associated lymphoid tissue (MALT) lymphoma pathogenesis is associated withHelicobacter pyloriinfection and genetic aberrations involving the nuclear factor κB signaling pathway. In this Review, gastric MALT lymphoma is presented an outstanding example of the close pathogenetic link between chronic inflammation and tumor development. Mucosa-associated lymphoid tissue (MALT) lymphoma, or extranodal marginal zone lymphoma of MALT, is an indolent B-cell non-Hodgkin lymphoma arising in lymphoid infiltrates that are induced by chronic inflammation in extranodal sites. The stomach is the most commonly affected organ, in which MALT lymphoma pathogenesis is clearly associated with Helicobacter pylori gastroduodenitis. Gastric MALT lymphoma has attracted attention because of the involvement of genetic aberrations in the nuclear factor κB (NFκB) pathway, one of the most investigated pathways in the fields of immunology and oncology. This Review presents gastric MALT lymphoma as an outstanding example of the close pathogenetic link between chronic inflammation and tumor development, and describes how this information can be integrated into daily clinical practice. Gastric MALT lymphoma is considered one of the best models of how genetic events lead to oncogenesis, determine tumor biology, dictate clinical behavior and represent viable therapeutic targets. Moreover, in view of the association of gastric MALT lymphoma with dysregulation of the NFκB pathway, this signaling pathway will be discussed in depth in both normal and pathological conditions, highlighting strategies to identify new therapeutic targets in this lymphoma." @default.
- W2021491719 created "2016-06-24" @default.
- W2021491719 creator A5003632939 @default.
- W2021491719 creator A5004036479 @default.
- W2021491719 creator A5075287370 @default.
- W2021491719 creator A5086292280 @default.
- W2021491719 creator A5090645179 @default.
- W2021491719 date "2010-05-04" @default.
- W2021491719 modified "2023-10-02" @default.
- W2021491719 title "Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development" @default.
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