FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021504231> ?p ?o ?g. }

• W2021504231 endingPage "690" @default.
• W2021504231 startingPage "679" @default.
• W2021504231 abstract "In this study, the effects of lead (Pb2+) on voltage-gated sodium channel currents (INa) were investigated in acutely dissociated rat hippocampal CA1 neurons using the conventional whole-cell patch-clamp technique. We found that Pb2+ reduced the amplitudes of INa in a concentration-dependent manner, and the effect could be washed out by extracellular application of 3mM EGTA. The results also showed that at the concentration of 100μM, Pb2+ decreased the activation threshold and the voltage at which the maximum INa current was evoked and caused negative shifts of INa steady-state activation curve, and enlarged INa tail-currents; Pb2+ induces a left shift of the steady-state inactivation curve, and delayed the recovery of INa from inactivation, and reduced the fraction of available sodium channels; Pb2+ delayed the activation of INa in a concentration- and voltage-dependent manner, and prolonged the time course of the fast inactivation of sodium channels; activity-dependent attenuation of INa was not altered by Pb2+. It was suggested that Pb2+ might exert its effects on sodium channels by binding a specific site on the extracellular side of sodium channels and dragging the IIS4 voltage sensor outwardly. The interaction of Pb2+ with voltage-dependent sodium channels may lead to change in electrical activity and contribute to worsen the neurotoxicological damage." @default.
• W2021504231 created "2016-06-24" @default.
• W2021504231 creator A5026388247 @default.
• W2021504231 creator A5034762017 @default.
• W2021504231 creator A5042820339 @default.
• W2021504231 creator A5067786455 @default.
• W2021504231 creator A5084203511 @default.
• W2021504231 date "2005-01-01" @default.
• W2021504231 modified "2023-09-25" @default.
• W2021504231 title "Effects of lead on voltage-gated sodium channels in rat hippocampal CA1 neurons" @default.
• W2021504231 cites W1532616787 @default.
• W2021504231 cites W1542790713 @default.
• W2021504231 cites W1850272931 @default.
• W2021504231 cites W1965522673 @default.
• W2021504231 cites W1970283692 @default.
• W2021504231 cites W1972459374 @default.
• W2021504231 cites W1976379806 @default.
• W2021504231 cites W1982469245 @default.
• W2021504231 cites W1985024251 @default.
• W2021504231 cites W1985940938 @default.
• W2021504231 cites W1993251008 @default.
• W2021504231 cites W1996437700 @default.
• W2021504231 cites W2002959402 @default.
• W2021504231 cites W2014706126 @default.
• W2021504231 cites W2019652289 @default.
• W2021504231 cites W2028637704 @default.
• W2021504231 cites W2028654569 @default.
• W2021504231 cites W2040341751 @default.
• W2021504231 cites W2041006552 @default.
• W2021504231 cites W2056481763 @default.
• W2021504231 cites W2057610250 @default.
• W2021504231 cites W2060091703 @default.
• W2021504231 cites W2063439463 @default.
• W2021504231 cites W2065568556 @default.
• W2021504231 cites W2087930285 @default.
• W2021504231 cites W2090981990 @default.
• W2021504231 cites W2094677101 @default.
• W2021504231 cites W2094786998 @default.
• W2021504231 cites W2098499866 @default.
• W2021504231 cites W2120771179 @default.
• W2021504231 cites W2144006183 @default.
• W2021504231 cites W2165375369 @default.
• W2021504231 cites W2255288257 @default.
• W2021504231 cites W2261409955 @default.
• W2021504231 doi "https://doi.org/10.1016/j.neuroscience.2005.02.039" @default.
• W2021504231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15896915" @default.
• W2021504231 hasPublicationYear "2005" @default.
• W2021504231 type Work @default.
• W2021504231 sameAs 2021504231 @default.
• W2021504231 citedByCount "19" @default.
• W2021504231 countsByYear W20215042312012 @default.
• W2021504231 countsByYear W20215042312013 @default.
• W2021504231 countsByYear W20215042312015 @default.
• W2021504231 countsByYear W20215042312016 @default.
• W2021504231 countsByYear W20215042312017 @default.
• W2021504231 countsByYear W20215042312018 @default.
• W2021504231 countsByYear W20215042312020 @default.
• W2021504231 countsByYear W20215042312021 @default.
• W2021504231 countsByYear W20215042312023 @default.
• W2021504231 crossrefType "journal-article" @default.
• W2021504231 hasAuthorship W2021504231A5026388247 @default.
• W2021504231 hasAuthorship W2021504231A5034762017 @default.
• W2021504231 hasAuthorship W2021504231A5042820339 @default.
• W2021504231 hasAuthorship W2021504231A5067786455 @default.
• W2021504231 hasAuthorship W2021504231A5084203511 @default.
• W2021504231 hasConcept C12554922 @default.
• W2021504231 hasConcept C134018914 @default.
• W2021504231 hasConcept C147944092 @default.
• W2021504231 hasConcept C148762608 @default.
• W2021504231 hasConcept C170493617 @default.
• W2021504231 hasConcept C178790620 @default.
• W2021504231 hasConcept C185592680 @default.
• W2021504231 hasConcept C2777658833 @default.
• W2021504231 hasConcept C28406088 @default.
• W2021504231 hasConcept C50952357 @default.
• W2021504231 hasConcept C519063684 @default.
• W2021504231 hasConcept C537181965 @default.
• W2021504231 hasConcept C55493867 @default.
• W2021504231 hasConcept C86803240 @default.
• W2021504231 hasConceptScore W2021504231C12554922 @default.
• W2021504231 hasConceptScore W2021504231C134018914 @default.
• W2021504231 hasConceptScore W2021504231C147944092 @default.
• W2021504231 hasConceptScore W2021504231C148762608 @default.
• W2021504231 hasConceptScore W2021504231C170493617 @default.
• W2021504231 hasConceptScore W2021504231C178790620 @default.
• W2021504231 hasConceptScore W2021504231C185592680 @default.
• W2021504231 hasConceptScore W2021504231C2777658833 @default.
• W2021504231 hasConceptScore W2021504231C28406088 @default.
• W2021504231 hasConceptScore W2021504231C50952357 @default.
• W2021504231 hasConceptScore W2021504231C519063684 @default.
• W2021504231 hasConceptScore W2021504231C537181965 @default.
• W2021504231 hasConceptScore W2021504231C55493867 @default.
• W2021504231 hasConceptScore W2021504231C86803240 @default.
• W2021504231 hasIssue "3" @default.
• W2021504231 hasLocation W20215042311 @default.
• W2021504231 hasLocation W20215042312 @default.
• W2021504231 hasOpenAccess W2021504231 @default.
• W2021504231 hasPrimaryLocation W20215042311 @default.

• next