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- W2021504493 abstract "Recent neuroimaging advances have stressed the interest of assessing hippocampal subfields separately rather than considering the hippocampus as a whole, notably to highlight specific effects of diseases on this structure. Whereas the pattern of hippocampal atrophy in Alzheimer's disease (AD) is relatively well-known (involving an early and marked atrophy of the CA1 subfield), the effect of normal aging is still a source of debate as discrepant findings have been reported. To further investigate this question, we developed a new high-resolution proton-density weighted magnetic resonance sequence using a 3-Tesla scanner, together with tracing guidelines to delineate hippocampal subfields. Three regions of interest (ROI) were manually drawn on both hippocampi of 50 healthy subjects between 18 and 68 years old and 10 patients with AD: CA1, Subiculum and Other (including CA2-3-4 and Dentate Gyrus). We also applied a simpler and less time-consuming method based on the widely-used automatic Voxel-Based Morphometry (VBM) technique onto standard T1-weighted images obtained in the same subjects. The effect of age was assessed with both methods in the healthy controls using correlation analyses, and patients with AD were compared to healthy elderly. A significant effect of age was observed on the volume of the subiculum with CA1 and Other subfields being relatively spared with age, while a decrease in the volume of CA1 was found in AD. Although less precise than the ROI technique, the VBM method led to consistent findings, showing a stronger effect of age on the medial border of the hippocampus corresponding to the subiculum while AD preferentially affected the lateral portions mainly superposing to the CA1 subfield (see figure below). The VBM automatic technique thus appears as a reliable alternative to assess volumetric changes within the hippocampus, especially to distinguish CA1 and subiculum subfields. Our finding of a specific effect of age on the subiculum are consistent with the developmental hypothesis (last-in first-out theory) and contrasts with the predominant vulnerability of the CA1 subfield in AD. Those results suggest that assessing the volume of hippocampal subfields may improve the discrimination between normal and pathological aging." @default.
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- W2021504493 date "2010-07-01" @default.
- W2021504493 modified "2023-10-18" @default.
- W2021504493 title "P4-057: A New MR Sequence on a 3T Scanner to Assess the Volume of Hippocampal Subfields: Contrasted Effects of Normal Aging and Alzheimer's Disease" @default.
- W2021504493 doi "https://doi.org/10.1016/j.jalz.2010.08.117" @default.
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