Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021505095> ?p ?o ?g. }
- W2021505095 endingPage "149" @default.
- W2021505095 startingPage "131" @default.
- W2021505095 abstract "Abstract. The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This review will focus on these mechanisms, i.e. regulation of cyclin‐dependent kinases (CDK) by cyclins, CDK inhibitors and phosphorylating events. The quality checkpoints activated after DNA damage are also discussed. The complexity of the regulation of the cell cycle is also reflected in the different alterations leading to aberrant cell proliferation and development of cancer. Consequently, targeting the cell cycle in general and CDK in particular presents unique opportunities for drug discovery. This review provides an overview of deregulation of the cell cycle in cancer. Different families of known CDK inhibitors acting by ATP competition are also discussed. Currently, at least three compounds with CDK inhibitory activity (flavopiridol, UCN‐01, roscovitine) have entered clinical trials." @default.
- W2021505095 created "2016-06-24" @default.
- W2021505095 creator A5015223856 @default.
- W2021505095 creator A5026477507 @default.
- W2021505095 creator A5040648159 @default.
- W2021505095 date "2003-06-01" @default.
- W2021505095 modified "2023-10-16" @default.
- W2021505095 title "The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer" @default.
- W2021505095 cites W1039919788 @default.
- W2021505095 cites W1245662471 @default.
- W2021505095 cites W129960861 @default.
- W2021505095 cites W139338291 @default.
- W2021505095 cites W14762771 @default.
- W2021505095 cites W1498881489 @default.
- W2021505095 cites W1527674890 @default.
- W2021505095 cites W1527716720 @default.
- W2021505095 cites W1531850676 @default.
- W2021505095 cites W1541806623 @default.
- W2021505095 cites W1545201063 @default.
- W2021505095 cites W1552426876 @default.
- W2021505095 cites W1564268429 @default.
- W2021505095 cites W1569698611 @default.
- W2021505095 cites W1578409462 @default.
- W2021505095 cites W1599757231 @default.
- W2021505095 cites W1635667563 @default.
- W2021505095 cites W1650185154 @default.
- W2021505095 cites W1657827244 @default.
- W2021505095 cites W1677118171 @default.
- W2021505095 cites W171936907 @default.
- W2021505095 cites W177595770 @default.
- W2021505095 cites W1813513289 @default.
- W2021505095 cites W1823168351 @default.
- W2021505095 cites W182915781 @default.
- W2021505095 cites W1857398401 @default.
- W2021505095 cites W1892085233 @default.
- W2021505095 cites W189835141 @default.
- W2021505095 cites W1919908042 @default.
- W2021505095 cites W194707462 @default.
- W2021505095 cites W1966115284 @default.
- W2021505095 cites W1967880683 @default.
- W2021505095 cites W1968050352 @default.
- W2021505095 cites W1969355167 @default.
- W2021505095 cites W1969469693 @default.
- W2021505095 cites W1969939692 @default.
- W2021505095 cites W1971140803 @default.
- W2021505095 cites W1975092706 @default.
- W2021505095 cites W1978406914 @default.
- W2021505095 cites W1979781336 @default.
- W2021505095 cites W1980534531 @default.
- W2021505095 cites W1981524094 @default.
- W2021505095 cites W1982622947 @default.
- W2021505095 cites W1982768428 @default.
- W2021505095 cites W1983202900 @default.
- W2021505095 cites W1983751803 @default.
- W2021505095 cites W1984226397 @default.
- W2021505095 cites W1985075123 @default.
- W2021505095 cites W1986880443 @default.
- W2021505095 cites W1988678729 @default.
- W2021505095 cites W1990743609 @default.
- W2021505095 cites W1991101546 @default.
- W2021505095 cites W1991494214 @default.
- W2021505095 cites W1994066190 @default.
- W2021505095 cites W1994082723 @default.
- W2021505095 cites W1994949503 @default.
- W2021505095 cites W1995527354 @default.
- W2021505095 cites W1996413533 @default.
- W2021505095 cites W1996711598 @default.
- W2021505095 cites W1997551404 @default.
- W2021505095 cites W1998919695 @default.
- W2021505095 cites W1999319877 @default.
- W2021505095 cites W2000798159 @default.
- W2021505095 cites W2003907692 @default.
- W2021505095 cites W2004008931 @default.
- W2021505095 cites W2009884967 @default.
- W2021505095 cites W2010452319 @default.
- W2021505095 cites W2015050458 @default.
- W2021505095 cites W2015066175 @default.
- W2021505095 cites W2015446431 @default.
- W2021505095 cites W2015519364 @default.
- W2021505095 cites W2015636345 @default.
- W2021505095 cites W2015902966 @default.
- W2021505095 cites W2016552601 @default.
- W2021505095 cites W2017693259 @default.
- W2021505095 cites W2019918282 @default.
- W2021505095 cites W2020520526 @default.
- W2021505095 cites W2021457628 @default.
- W2021505095 cites W2021722888 @default.
- W2021505095 cites W2021800215 @default.
- W2021505095 cites W2024867953 @default.
- W2021505095 cites W2026421871 @default.
- W2021505095 cites W2027376766 @default.
- W2021505095 cites W2027614463 @default.
- W2021505095 cites W2029080338 @default.
- W2021505095 cites W2032236714 @default.
- W2021505095 cites W2036648542 @default.
- W2021505095 cites W2037652830 @default.
- W2021505095 cites W2039557096 @default.
- W2021505095 cites W2039839254 @default.