FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021505175> ?p ?o ?g. }

• W2021505175 endingPage "2103" @default.
• W2021505175 startingPage "2099" @default.
• W2021505175 abstract "Overactivity of the hexosamine biosynthetic pathway may underlie hyperglycemia-associated insulin resistance, but to date human studies are lacking. Hexosamine pathway activation can be mimicked by glucosamine (GlcN). In the present placebo-controlled study we determined whether GlcN infusion affects insulin resistance in vivo. In 18 healthy subjects, we applied the double forearm balance technique (infused arm vs. control arm) combined with the euglycemic hyperinsulinemic clamp (60 mU/m(2).min insulin) for at least 300 min. During the clamp, subjects received infusions in the brachial artery of 4 micromol/dL.min GlcN from 90-240 min (n = 6) or from 0-300 min (n = 6) or saline (placebo; n = 6). We studied the effects of GlcN on forearm glucose uptake (FGU; infused arm vs. control arm, and vs. placebo experiments) and on whole body glucose uptake. GlcN infusion raised the plasma GlcN concentration in the infusion arms to 0.42 +/- 0.14 and 0.81 +/- 0.46 mmol/L; plasma GlcN remained very low (< 0.07 mmol/L) in the control arms and in the placebo group. GlcN infusion did not change forearm blood flow. During insulin, FGU increased more than 10-fold. At all time points, FGU was similar in the GlcN-infused arm compared with the control arm and was not different from FGU in the placebo experiments. Similar results were obtained for forearm arteriovenous glucose differences or extraction and for whole body glucose uptake. Thus, despite relevant GlcN concentrations for 5 h in the infused forearm, GlcN had no effect on insulin-induced glucose uptake. These results do not support involvement of the hexosamine pathway in the regulation of insulin sensitivity in humans, at least not in the short-term setting." @default.
• W2021505175 created "2016-06-24" @default.
• W2021505175 creator A5011314920 @default.
• W2021505175 creator A5027784857 @default.
• W2021505175 creator A5030258325 @default.
• W2021505175 creator A5043734405 @default.
• W2021505175 creator A5060526287 @default.
• W2021505175 creator A5079360914 @default.
• W2021505175 date "2001-05-01" @default.
• W2021505175 modified "2023-10-12" @default.
• W2021505175 title "Short-Term Glucosamine Infusion Does Not Affect Insulin Sensitivity in Humans1" @default.
• W2021505175 cites W1590732591 @default.
• W2021505175 cites W1605680188 @default.
• W2021505175 cites W1612870394 @default.
• W2021505175 cites W1729962335 @default.
• W2021505175 cites W1993842351 @default.
• W2021505175 cites W1999351520 @default.
• W2021505175 cites W2027153646 @default.
• W2021505175 cites W2034911881 @default.
• W2021505175 cites W2035194670 @default.
• W2021505175 cites W2037526260 @default.
• W2021505175 cites W2048670619 @default.
• W2021505175 cites W2056259190 @default.
• W2021505175 cites W2064332050 @default.
• W2021505175 cites W2067702028 @default.
• W2021505175 cites W2083974079 @default.
• W2021505175 cites W2089266364 @default.
• W2021505175 cites W2094359677 @default.
• W2021505175 cites W2099914905 @default.
• W2021505175 cites W2101318760 @default.
• W2021505175 cites W2103642791 @default.
• W2021505175 cites W2105912552 @default.
• W2021505175 cites W2108718331 @default.
• W2021505175 cites W2114508339 @default.
• W2021505175 cites W2118505283 @default.
• W2021505175 cites W2119714702 @default.
• W2021505175 cites W2268890861 @default.
• W2021505175 cites W65957098 @default.
• W2021505175 doi "https://doi.org/10.1210/jcem.86.5.7470" @default.
• W2021505175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11344213" @default.
• W2021505175 hasPublicationYear "2001" @default.
• W2021505175 type Work @default.
• W2021505175 sameAs 2021505175 @default.
• W2021505175 citedByCount "29" @default.
• W2021505175 countsByYear W20215051752015 @default.
• W2021505175 countsByYear W20215051752016 @default.
• W2021505175 countsByYear W20215051752019 @default.
• W2021505175 countsByYear W20215051752022 @default.
• W2021505175 crossrefType "journal-article" @default.
• W2021505175 hasAuthorship W2021505175A5011314920 @default.
• W2021505175 hasAuthorship W2021505175A5027784857 @default.
• W2021505175 hasAuthorship W2021505175A5030258325 @default.
• W2021505175 hasAuthorship W2021505175A5043734405 @default.
• W2021505175 hasAuthorship W2021505175A5060526287 @default.
• W2021505175 hasAuthorship W2021505175A5079360914 @default.
• W2021505175 hasBestOaLocation W20215051751 @default.
• W2021505175 hasConcept C126322002 @default.
• W2021505175 hasConcept C134018914 @default.
• W2021505175 hasConcept C141071460 @default.
• W2021505175 hasConcept C142724271 @default.
• W2021505175 hasConcept C204787440 @default.
• W2021505175 hasConcept C27081682 @default.
• W2021505175 hasConcept C2777391703 @default.
• W2021505175 hasConcept C2777397205 @default.
• W2021505175 hasConcept C2777866211 @default.
• W2021505175 hasConcept C2778808658 @default.
• W2021505175 hasConcept C2779306644 @default.
• W2021505175 hasConcept C2780214079 @default.
• W2021505175 hasConcept C2780352109 @default.
• W2021505175 hasConcept C71924100 @default.
• W2021505175 hasConceptScore W2021505175C126322002 @default.
• W2021505175 hasConceptScore W2021505175C134018914 @default.
• W2021505175 hasConceptScore W2021505175C141071460 @default.
• W2021505175 hasConceptScore W2021505175C142724271 @default.
• W2021505175 hasConceptScore W2021505175C204787440 @default.
• W2021505175 hasConceptScore W2021505175C27081682 @default.
• W2021505175 hasConceptScore W2021505175C2777391703 @default.
• W2021505175 hasConceptScore W2021505175C2777397205 @default.
• W2021505175 hasConceptScore W2021505175C2777866211 @default.
• W2021505175 hasConceptScore W2021505175C2778808658 @default.
• W2021505175 hasConceptScore W2021505175C2779306644 @default.
• W2021505175 hasConceptScore W2021505175C2780214079 @default.
• W2021505175 hasConceptScore W2021505175C2780352109 @default.
• W2021505175 hasConceptScore W2021505175C71924100 @default.
• W2021505175 hasIssue "5" @default.
• W2021505175 hasLocation W20215051751 @default.
• W2021505175 hasLocation W20215051752 @default.
• W2021505175 hasOpenAccess W2021505175 @default.
• W2021505175 hasPrimaryLocation W20215051751 @default.
• W2021505175 hasRelatedWork W2002175422 @default.
• W2021505175 hasRelatedWork W2012273189 @default.
• W2021505175 hasRelatedWork W2049881486 @default.
• W2021505175 hasRelatedWork W2054690921 @default.
• W2021505175 hasRelatedWork W2079309060 @default.
• W2021505175 hasRelatedWork W2094672900 @default.
• W2021505175 hasRelatedWork W2161160210 @default.
• W2021505175 hasRelatedWork W2410789767 @default.
• W2021505175 hasRelatedWork W2467347426 @default.

• next