Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021513298> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2021513298 abstract "To investigate the effect of H. trifoliata on: (a) acetic acid-induced ulcers, (b) food intake, (c) water intake, (d) weight gain, (e) gastric acid secretion in rats.Comparative study.Laboratory.20 female Sprague Dawley rats (220 to 250 g) with acetic acid-induced peptic ulcers randomly assigned to test and control groups (n = 10). The test rats were allowed water and normal rat diet comprising 20% H. trifoliata ('Dombwe) and 'Imfe nkulu' in Shona and Ndebele respectively) for 17 days after ulceration while control rats were allowed water and normal rat diet for 17 days after ulceration. Thirty six other rats were prepared to study the effect of H. trifoliata on gastric and acid secretion stimulated by histamine, gastrin and carbachol.Photographs of the gross anatomy and histology of test and control rat stomachs were taken. Daily food and water intake, weekly weight gain and gastric acid secretion were measured in the test and control rats.17 days following the consumption of the H. trifoliata containing diet, macroscopically, no ulcers were found on the outer surface of the stomach walls of test rats. However, histological examination revealed traces of ulcer at the sites where ulcers were induced previously. In contrast, 70% of the control rats still had ulcers on the surface of their stomach walls. Histological examination showed massive denuded mucosa and submucosa at the ulcer sites which are signs of severe ulceration. Food intake in both groups was not significantly different except during the first three days when test rats consumed significantly less food (p < 0.01) than control rats. Daily water intake and weekly weight gain were also not significantly different in the test and control groups. H. trifoliata had no significant effect on gastric acid secretion stimulated by histamine, gastrin and carbachol.H. trifoliata does not affect daily food and water intake and weekly weight gain in rats. It also does not affect histamine, gastrin and carbachol-stimulated acid secretion in rats. However, H. trifoliata accelerates the healing of acetic acid-induced peptic ulcer in rats. This may validate the use of H. trifoliata in the treatment of peptic ulcer in humans." @default.
- W2021513298 created "2016-06-24" @default.
- W2021513298 creator A5002796596 @default.
- W2021513298 creator A5031561013 @default.
- W2021513298 creator A5032636378 @default.
- W2021513298 creator A5047745204 @default.
- W2021513298 creator A5061626561 @default.
- W2021513298 creator A5088776004 @default.
- W2021513298 date "1999-02-01" @default.
- W2021513298 modified "2023-09-27" @default.
- W2021513298 title "<i>Heteromorpha trifoliata </i> (Dombwe) accelerates acetic acid-induced peptic ulters: a preliminary study in the rat" @default.
- W2021513298 doi "https://doi.org/10.4314/cajm.v45i2.8449" @default.
- W2021513298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10444897" @default.
- W2021513298 hasPublicationYear "1999" @default.
- W2021513298 type Work @default.
- W2021513298 sameAs 2021513298 @default.
- W2021513298 citedByCount "1" @default.
- W2021513298 countsByYear W20215132982013 @default.
- W2021513298 crossrefType "journal-article" @default.
- W2021513298 hasAuthorship W2021513298A5002796596 @default.
- W2021513298 hasAuthorship W2021513298A5031561013 @default.
- W2021513298 hasAuthorship W2021513298A5032636378 @default.
- W2021513298 hasAuthorship W2021513298A5047745204 @default.
- W2021513298 hasAuthorship W2021513298A5061626561 @default.
- W2021513298 hasAuthorship W2021513298A5088776004 @default.
- W2021513298 hasConcept C1122143 @default.
- W2021513298 hasConcept C126322002 @default.
- W2021513298 hasConcept C185592680 @default.
- W2021513298 hasConcept C2776673659 @default.
- W2021513298 hasConcept C2777504413 @default.
- W2021513298 hasConcept C2779052585 @default.
- W2021513298 hasConcept C2779390736 @default.
- W2021513298 hasConcept C2779422922 @default.
- W2021513298 hasConcept C2780656511 @default.
- W2021513298 hasConcept C55493867 @default.
- W2021513298 hasConcept C57742111 @default.
- W2021513298 hasConcept C71924100 @default.
- W2021513298 hasConcept C90924648 @default.
- W2021513298 hasConceptScore W2021513298C1122143 @default.
- W2021513298 hasConceptScore W2021513298C126322002 @default.
- W2021513298 hasConceptScore W2021513298C185592680 @default.
- W2021513298 hasConceptScore W2021513298C2776673659 @default.
- W2021513298 hasConceptScore W2021513298C2777504413 @default.
- W2021513298 hasConceptScore W2021513298C2779052585 @default.
- W2021513298 hasConceptScore W2021513298C2779390736 @default.
- W2021513298 hasConceptScore W2021513298C2779422922 @default.
- W2021513298 hasConceptScore W2021513298C2780656511 @default.
- W2021513298 hasConceptScore W2021513298C55493867 @default.
- W2021513298 hasConceptScore W2021513298C57742111 @default.
- W2021513298 hasConceptScore W2021513298C71924100 @default.
- W2021513298 hasConceptScore W2021513298C90924648 @default.
- W2021513298 hasIssue "2" @default.
- W2021513298 hasLocation W20215132981 @default.
- W2021513298 hasLocation W20215132982 @default.
- W2021513298 hasOpenAccess W2021513298 @default.
- W2021513298 hasPrimaryLocation W20215132981 @default.
- W2021513298 hasRelatedWork W2041816807 @default.
- W2021513298 hasRelatedWork W2182282277 @default.
- W2021513298 hasRelatedWork W2182302678 @default.
- W2021513298 hasRelatedWork W2183818090 @default.
- W2021513298 hasRelatedWork W2235402078 @default.
- W2021513298 hasRelatedWork W2272518740 @default.
- W2021513298 hasRelatedWork W2327884845 @default.
- W2021513298 hasRelatedWork W2389779412 @default.
- W2021513298 hasRelatedWork W2412629467 @default.
- W2021513298 hasRelatedWork W2418434537 @default.
- W2021513298 hasRelatedWork W2771347108 @default.
- W2021513298 hasRelatedWork W2789449664 @default.
- W2021513298 hasRelatedWork W2991461354 @default.
- W2021513298 hasRelatedWork W3045083307 @default.
- W2021513298 hasRelatedWork W3147380209 @default.
- W2021513298 hasRelatedWork W3208582666 @default.
- W2021513298 hasRelatedWork W2181892166 @default.
- W2021513298 hasRelatedWork W2181980487 @default.
- W2021513298 hasRelatedWork W2926311477 @default.
- W2021513298 hasRelatedWork W3087687017 @default.
- W2021513298 hasVolume "45" @default.
- W2021513298 isParatext "false" @default.
- W2021513298 isRetracted "false" @default.
- W2021513298 magId "2021513298" @default.
- W2021513298 workType "article" @default.