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• W2021519886 abstract "Neural regulation of energy expenditure is incompletely understood. By genetically disrupting GABAergic transmission in a cell-specific fashion, and by combining this with selective pharmacogenetic activation and optogenetic mapping techniques, we have uncovered an arcuate-based circuit that selectively drives energy expenditure. Specifically, mice lacking synaptic GABA release from RIP-Cre neurons have reduced energy expenditure, become obese and are extremely sensitive to high-fat diet-induced obesity, the latter due to defective diet-induced thermogenesis. Leptin's ability to stimulate thermogenesis, but not to reduce feeding, is markedly attenuated. Acute, selective activation of arcuate GABAergic RIP-Cre neurons, which monosynaptically innervate PVH neurons projecting to the NTS, rapidly stimulates brown fat and increases energy expenditure but does not affect feeding. Importantly, this response is dependent upon GABA release from RIP-Cre neurons. Thus, GABAergic RIP-Cre neurons in the arcuate selectively drive energy expenditure, contribute to leptin's stimulatory effect on thermogenesis, and protect against diet-induced obesity." @default.
• W2021519886 created "2016-06-24" @default.
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• W2021519886 date "2012-10-01" @default.
• W2021519886 modified "2023-10-15" @default.
• W2021519886 title "GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure" @default.
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• W2021519886 cites W1967238067 @default.
• W2021519886 cites W1973502241 @default.
• W2021519886 cites W1976555898 @default.
• W2021519886 cites W1981025527 @default.
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• W2021519886 doi "https://doi.org/10.1016/j.cell.2012.09.020" @default.
• W2021519886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3500616" @default.
• W2021519886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23101631" @default.
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