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- W2021520444 startingPage "552" @default.
- W2021520444 abstract "Cytokines are key to control cellular communication. Interleukin-31 (IL-31) was recently discovered as a new member of the IL-6 family of cytokines. IL-31 signals through a heterodimeric receptor composed of OSMR and IL-31RA, a complex that stimulates the JAK-STAT, the RAS/ERK and the PI3K/AKT signal transduction pathways. The available data suggests that IL-31 is important for both innate and adaptive immunity in tissues that are in close contact with the environment, i.e. the skin, the airways and the lung, and the lining of the intestine. Enhanced expression of IL-31 is associated with a number of diseases, including pruritic diseases such as atopic dermatitis, but also in allergy and inflammatory bowel disease. In these tissues IL-31 coordinates the interaction of different immune cells, including T-cells, mast cells, and eosinophils, with epithelial cells. In this review we have summarized the available data on IL-31 and its receptor, their expression pattern and how they are regulated. We describe the current state of knowledge of the involvement of IL-31 in diseases, both in humans and in mouse models. From these studies it is becoming clear that IL-31 plays an important role in the proper functioning of the skin and of airway and intestinal epithelia. The findings available suggest that IL-31 might be an interesting target for directed drug therapy." @default.
- W2021520444 created "2016-06-24" @default.
- W2021520444 creator A5041462448 @default.
- W2021520444 creator A5058501596 @default.
- W2021520444 creator A5079567414 @default.
- W2021520444 creator A5090315796 @default.
- W2021520444 date "2012-06-01" @default.
- W2021520444 modified "2023-10-05" @default.
- W2021520444 title "Signaling by IL-31 and functional consequences" @default.
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