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• W2021521298 abstract "Photothermal optical coherence tomography (PT-OCT) is a potentially powerful tool for molecular imaging. Here, we characterize PT-OCT imaging of gold nanorod (GNR) contrast agents in phantoms, and we apply these techniques for in vivo GNR imaging. The PT-OCT signal was compared to the bio-heat equation in phantoms, and in vivo PT-OCT images were acquired from subcutaneous 400 pM GNR Matrigel injections into mice. Experiments revealed that PT-OCT signals varied as predicted by the bio-heat equation, with significant PT-OCT signal increases at 7.5 pM GNR compared to a scattering control (p < 0.01) while imaging in common path configuration. In vivo PT-OCT images demonstrated an appreciable increase in signal in the presence of GNRs compared to controls. Additionally, in vivo PT-OCT GNR signals were spatially distinct from blood vessels imaged with Doppler OCT. We anticipate that the demonstrated in vivo PT-OCT sensitivity to GNR contrast agents is sufficient to image molecular expression in vivo. Therefore, this work demonstrates the translation of PT-OCT to in vivo imaging and represents the next step towards its use as an in vivo molecular imaging tool." @default.
• W2021521298 created "2016-06-24" @default.
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• W2021521298 date "2012-10-17" @default.
• W2021521298 modified "2023-09-25" @default.
• W2021521298 title "In vivo photothermal optical coherence tomography of gold nanorod contrast agents" @default.
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• W2021521298 doi "https://doi.org/10.1364/boe.3.002881" @default.
• W2021521298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3493242" @default.
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