FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021522748> ?p ?o ?g. }

• W2021522748 endingPage "735" @default.
• W2021522748 startingPage "721" @default.
• W2021522748 abstract "Recent evidence has shown that bone marrow stromal cells (BMSCs) may exhibit immuno-suppression activities through soluble mediators and direct cell–cell contact, but how these processes are modulated has been poorly understood. In this study, we show that the Notch signaling pathway participates in the modulation of BMSCs to elicit their immuno-suppressive roles. In a murine lethal acute graft versus host disease (aGvHD) model, BMSCs deficient for RBP-J, the critical transcription factor mediating signaling from all four mammalian Notch receptors, failed to delay the development of the disease. RBP-J deficient BMSCs were not able to inhibit the proliferation and activation of allogenic T-cells. Moreover, RBP-J deficient BMSCs could not down-regulate the expression of MHC II and co-stimulation molecules CD80 and CD86 on dendritic cells (DCs). The antigen presentation capacity of DCs co-cultured with RBP-J deficient BMSCs was not impaired in contrast to wild type BMSCs. Furthermore, we showed that the productions of IL-6 and PGE2, two critical molecules mediating the immuno-suppressive activities of BMSCs, were reduced significantly in RBP-J deficient BMSCs. Both of the two molecules were importantly involved in the regulation of BMSCs by Notch signaling. In conclusion, our data suggests that the immuno-suppressive effects of BMSCs in aGvHD are dependent on Notch-RBP-J signaling, which regulates the productions of IL-6 and PGE2." @default.
• W2021522748 created "2016-06-24" @default.
• W2021522748 creator A5003459626 @default.
• W2021522748 creator A5013977675 @default.
• W2021522748 creator A5027475930 @default.
• W2021522748 creator A5032212794 @default.
• W2021522748 creator A5032334302 @default.
• W2021522748 creator A5050791885 @default.
• W2021522748 creator A5053488408 @default.
• W2021522748 creator A5059204683 @default.
• W2021522748 creator A5071918408 @default.
• W2021522748 creator A5077043713 @default.
• W2021522748 creator A5079218922 @default.
• W2021522748 creator A5083340325 @default.
• W2021522748 creator A5085240549 @default.
• W2021522748 date "2013-09-01" @default.
• W2021522748 modified "2023-10-16" @default.
• W2021522748 title "Notch-RBP-J signaling is required by bone marrow stromal cells for the treatment of acute graft versus host disease" @default.
• W2021522748 cites W1483295852 @default.
• W2021522748 cites W1499992835 @default.
• W2021522748 cites W1566942448 @default.
• W2021522748 cites W1574633890 @default.
• W2021522748 cites W1597188925 @default.
• W2021522748 cites W1771412454 @default.
• W2021522748 cites W1967217261 @default.
• W2021522748 cites W1971218073 @default.
• W2021522748 cites W1982408656 @default.
• W2021522748 cites W1985410547 @default.
• W2021522748 cites W1989972105 @default.
• W2021522748 cites W1993640536 @default.
• W2021522748 cites W1997082970 @default.
• W2021522748 cites W1998233759 @default.
• W2021522748 cites W2002753637 @default.
• W2021522748 cites W2007740082 @default.
• W2021522748 cites W2009700765 @default.
• W2021522748 cites W2013758266 @default.
• W2021522748 cites W2021916724 @default.
• W2021522748 cites W2022481684 @default.
• W2021522748 cites W2024088021 @default.
• W2021522748 cites W2025294489 @default.
• W2021522748 cites W2035976926 @default.
• W2021522748 cites W2037174379 @default.
• W2021522748 cites W2038970416 @default.
• W2021522748 cites W2044695442 @default.
• W2021522748 cites W2047003816 @default.
• W2021522748 cites W2053205331 @default.
• W2021522748 cites W2064866087 @default.
• W2021522748 cites W2078489918 @default.
• W2021522748 cites W2081867547 @default.
• W2021522748 cites W2082739503 @default.
• W2021522748 cites W2086699558 @default.
• W2021522748 cites W2088964957 @default.
• W2021522748 cites W2090894988 @default.
• W2021522748 cites W2095666785 @default.
• W2021522748 cites W2096166085 @default.
• W2021522748 cites W2103412440 @default.
• W2021522748 cites W2112315511 @default.
• W2021522748 cites W2116505148 @default.
• W2021522748 cites W2131004666 @default.
• W2021522748 cites W2133982451 @default.
• W2021522748 cites W2138946470 @default.
• W2021522748 cites W2140099354 @default.
• W2021522748 cites W2149557024 @default.
• W2021522748 cites W2150089458 @default.
• W2021522748 cites W2151536540 @default.
• W2021522748 cites W2152765064 @default.
• W2021522748 cites W2154861644 @default.
• W2021522748 cites W2157293906 @default.
• W2021522748 cites W2158780936 @default.
• W2021522748 cites W2159358845 @default.
• W2021522748 cites W2161497340 @default.
• W2021522748 cites W2162624576 @default.
• W2021522748 cites W2163559266 @default.
• W2021522748 cites W2332590159 @default.
• W2021522748 doi "https://doi.org/10.1016/j.scr.2013.04.009" @default.
• W2021522748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23735298" @default.
• W2021522748 hasPublicationYear "2013" @default.
• W2021522748 type Work @default.
• W2021522748 sameAs 2021522748 @default.
• W2021522748 citedByCount "14" @default.
• W2021522748 countsByYear W20215227482014 @default.
• W2021522748 countsByYear W20215227482015 @default.
• W2021522748 countsByYear W20215227482016 @default.
• W2021522748 countsByYear W20215227482017 @default.
• W2021522748 countsByYear W20215227482019 @default.
• W2021522748 countsByYear W20215227482020 @default.
• W2021522748 countsByYear W20215227482022 @default.
• W2021522748 crossrefType "journal-article" @default.
• W2021522748 hasAuthorship W2021522748A5003459626 @default.
• W2021522748 hasAuthorship W2021522748A5013977675 @default.
• W2021522748 hasAuthorship W2021522748A5027475930 @default.
• W2021522748 hasAuthorship W2021522748A5032212794 @default.
• W2021522748 hasAuthorship W2021522748A5032334302 @default.
• W2021522748 hasAuthorship W2021522748A5050791885 @default.
• W2021522748 hasAuthorship W2021522748A5053488408 @default.
• W2021522748 hasAuthorship W2021522748A5059204683 @default.
• W2021522748 hasAuthorship W2021522748A5071918408 @default.
• W2021522748 hasAuthorship W2021522748A5077043713 @default.

• next