FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021525060> ?p ?o ?g. }

• W2021525060 endingPage "3704" @default.
• W2021525060 startingPage "3696" @default.
• W2021525060 abstract "Reduced sensitivity to insulin in adipose, muscle, and liver tissues is a hallmark of type 2 diabetes. Animal models and patients with type 2 diabetes exhibit elevated levels of circulating retinol-binding protein (RBP4), and RBP4 can induce insulin resistance in mice. However, little is known about how RBP4 affects insulin signaling. We examined the mechanisms of action of RBP4 in primary human adipocytes. RBP4-treated adipocytes exhibited the same molecular defects in insulin signaling, via IRS1 to MAP kinase, as in adipocytes from patients with type 2 diabetes. Without affecting autophosphorylation of the insulin receptor, RBP4 blocked the insulin-stimulated phosphorylation of IRS1 at serine (307) [corresponding to serine (302) in the murine sequence] and concomitantly increased the EC50 (from 0.5 to 2 nM) for insulin stimulation of IRS1 phosphorylation at tyrosine. The phosphorylation of IRS1 at serine (312) [corresponding to serine (307) in the murine sequence] was not affected in cells from diabetic patients and was also not affected by RBP4. The EC50 for insulin stimulation of downstream phosphorylation of MAP kinase ERK1/2 was increased (from 0.2 to 0.8 nM) by RBP4. We show that ERK1/2 phosphorylation is similarly impaired in adipocytes from patients with type 2 diabetes. However, the sensitivity to insulin for downstream signaling to control of protein kinase B and glucose uptake was not affected by RBP4. When insulin-resistant adipocytes from patients with type 2 diabetes were incubated with antibodies against RBP4, insulin-induced phosphorylation of IRS1 at serine (307) was normalized and the EC50 for insulin stimulation of ERK1/2 phosphorylation was reduced. Endogenous levels of RBP4 were markedly reduced in adipocytes from obese or type 2 diabetic subjects, whereas expression levels of RBP4 mRNA were unaffected. These findings indicate that RBP4 may be released from diabetic adipocytes and act locally to inhibit phosphorylation of IRS1 at serine (307), a phosphorylation site that may integrate nutrient sensing with insulin signaling." @default.
• W2021525060 created "2016-06-24" @default.
• W2021525060 creator A5050009863 @default.
• W2021525060 creator A5060423672 @default.
• W2021525060 creator A5061451767 @default.
• W2021525060 creator A5062567060 @default.
• W2021525060 creator A5064006046 @default.
• W2021525060 creator A5080323249 @default.
• W2021525060 date "2007-06-15" @default.
• W2021525060 modified "2023-09-24" @default.
• W2021525060 title "Retinol‐binding protein‐4 attenuates insulin‐induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes" @default.
• W2021525060 cites W1529541248 @default.
• W2021525060 cites W1547232376 @default.
• W2021525060 cites W1773423156 @default.
• W2021525060 cites W1795759720 @default.
• W2021525060 cites W1886154307 @default.
• W2021525060 cites W1971825456 @default.
• W2021525060 cites W1979030077 @default.
• W2021525060 cites W2008720923 @default.
• W2021525060 cites W2013252945 @default.
• W2021525060 cites W2014887370 @default.
• W2021525060 cites W2018054347 @default.
• W2021525060 cites W2019653203 @default.
• W2021525060 cites W2040365189 @default.
• W2021525060 cites W2052829979 @default.
• W2021525060 cites W2061597050 @default.
• W2021525060 cites W2073795169 @default.
• W2021525060 cites W2084521532 @default.
• W2021525060 cites W2092136583 @default.
• W2021525060 cites W2098781003 @default.
• W2021525060 cites W2117700932 @default.
• W2021525060 cites W2123381133 @default.
• W2021525060 cites W2124948826 @default.
• W2021525060 cites W2135447862 @default.
• W2021525060 cites W2406460387 @default.
• W2021525060 cites W2468814072 @default.
• W2021525060 doi "https://doi.org/10.1096/fj.07-8173com" @default.
• W2021525060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17575262" @default.
• W2021525060 hasPublicationYear "2007" @default.
• W2021525060 type Work @default.
• W2021525060 sameAs 2021525060 @default.
• W2021525060 citedByCount "119" @default.
• W2021525060 countsByYear W20215250602012 @default.
• W2021525060 countsByYear W20215250602013 @default.
• W2021525060 countsByYear W20215250602014 @default.
• W2021525060 countsByYear W20215250602015 @default.
• W2021525060 countsByYear W20215250602016 @default.
• W2021525060 countsByYear W20215250602017 @default.
• W2021525060 countsByYear W20215250602018 @default.
• W2021525060 countsByYear W20215250602019 @default.
• W2021525060 countsByYear W20215250602020 @default.
• W2021525060 countsByYear W20215250602021 @default.
• W2021525060 countsByYear W20215250602022 @default.
• W2021525060 crossrefType "journal-article" @default.
• W2021525060 hasAuthorship W2021525060A5050009863 @default.
• W2021525060 hasAuthorship W2021525060A5060423672 @default.
• W2021525060 hasAuthorship W2021525060A5061451767 @default.
• W2021525060 hasAuthorship W2021525060A5062567060 @default.
• W2021525060 hasAuthorship W2021525060A5064006046 @default.
• W2021525060 hasAuthorship W2021525060A5080323249 @default.
• W2021525060 hasConcept C112446052 @default.
• W2021525060 hasConcept C11960822 @default.
• W2021525060 hasConcept C126322002 @default.
• W2021525060 hasConcept C134018914 @default.
• W2021525060 hasConcept C150109051 @default.
• W2021525060 hasConcept C185592680 @default.
• W2021525060 hasConcept C185967709 @default.
• W2021525060 hasConcept C194832188 @default.
• W2021525060 hasConcept C197902417 @default.
• W2021525060 hasConcept C201624660 @default.
• W2021525060 hasConcept C2776465410 @default.
• W2021525060 hasConcept C2777180221 @default.
• W2021525060 hasConcept C2777391703 @default.
• W2021525060 hasConcept C2779306644 @default.
• W2021525060 hasConcept C555293320 @default.
• W2021525060 hasConcept C71924100 @default.
• W2021525060 hasConcept C86803240 @default.
• W2021525060 hasConcept C95444343 @default.
• W2021525060 hasConcept C97029542 @default.
• W2021525060 hasConceptScore W2021525060C112446052 @default.
• W2021525060 hasConceptScore W2021525060C11960822 @default.
• W2021525060 hasConceptScore W2021525060C126322002 @default.
• W2021525060 hasConceptScore W2021525060C134018914 @default.
• W2021525060 hasConceptScore W2021525060C150109051 @default.
• W2021525060 hasConceptScore W2021525060C185592680 @default.
• W2021525060 hasConceptScore W2021525060C185967709 @default.
• W2021525060 hasConceptScore W2021525060C194832188 @default.
• W2021525060 hasConceptScore W2021525060C197902417 @default.
• W2021525060 hasConceptScore W2021525060C201624660 @default.
• W2021525060 hasConceptScore W2021525060C2776465410 @default.
• W2021525060 hasConceptScore W2021525060C2777180221 @default.
• W2021525060 hasConceptScore W2021525060C2777391703 @default.
• W2021525060 hasConceptScore W2021525060C2779306644 @default.
• W2021525060 hasConceptScore W2021525060C555293320 @default.
• W2021525060 hasConceptScore W2021525060C71924100 @default.
• W2021525060 hasConceptScore W2021525060C86803240 @default.
• W2021525060 hasConceptScore W2021525060C95444343 @default.
• W2021525060 hasConceptScore W2021525060C97029542 @default.

• next