FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021525451> ?p ?o ?g. }

• W2021525451 endingPage "4986" @default.
• W2021525451 startingPage "4975" @default.
• W2021525451 abstract "Abstract Purpose: We have previously reported that many types of tumors can induce changes in human T cells that lead to the acquisition of suppressive function and phenotypic alterations resembling those found in senescent T cells. In the present study, we find a role for interleukin 7 (IL-7) in protecting T cells from these changes and further define involved signaling pathways. Experimental Design: We evaluated the ability of IL-7 treatment to prevent the gain of suppressive function and phenotypic alterations in human T cells after a short coculture with tumor cells in vitro. We then used inhibitors of components of the phosphoinositide 3-kinase (PI3K)/AKT pathway and short interfering RNA knockdown of Mcl-1 and Bim to evaluate the role of these signaling pathways in IL-7 protection. Results: We found that IL-7 inhibits CD27/CD28 loss and maintains proliferative capacity, IL-2 production, and reduced suppressive function. The protective ability of IL-7 depended on activation of the PI3K/AKT pathway, which inhibited activation of glycogen synthase kinase 3β, which, in turn, prevented the phosphorylation and loss of Mcl-1. We further showed a key role for Mcl-1 in that its knockdown or inhibition abrogated the effects of IL-7. In addition, knockdown of the Mcl-1 binding partner and proapoptotic protein Bim protected T cells from these dysfunctional alterations. Conclusion: These observations confirm the role for Bcl-2 family members in cytokine signaling and suggest that IL-7 treatment in combination with other immunotherapies could lead to new clinical strategies to maintain normal T-cell function and reduce tumor-induced generation of dysfunctional and suppressor T cells. Clin Cancer Res; 17(15); 4975–86. ©2011 AACR." @default.
• W2021525451 created "2016-06-24" @default.
• W2021525451 creator A5000555155 @default.
• W2021525451 creator A5001202734 @default.
• W2021525451 creator A5001572155 @default.
• W2021525451 creator A5010776860 @default.
• W2021525451 creator A5028801725 @default.
• W2021525451 creator A5032755285 @default.
• W2021525451 creator A5033608310 @default.
• W2021525451 creator A5063880073 @default.
• W2021525451 creator A5087859996 @default.
• W2021525451 date "2011-07-31" @default.
• W2021525451 modified "2023-10-16" @default.
• W2021525451 title "Interleukin-7 Inhibits Tumor-Induced CD27−CD28− Suppressor T Cells: Implications for Cancer Immunotherapy" @default.
• W2021525451 cites W1548372537 @default.
• W2021525451 cites W1577612079 @default.
• W2021525451 cites W1601461124 @default.
• W2021525451 cites W1631661663 @default.
• W2021525451 cites W1761214387 @default.
• W2021525451 cites W1971727526 @default.
• W2021525451 cites W1972315079 @default.
• W2021525451 cites W1976532231 @default.
• W2021525451 cites W1977812814 @default.
• W2021525451 cites W1978432163 @default.
• W2021525451 cites W1978798271 @default.
• W2021525451 cites W1979003707 @default.
• W2021525451 cites W1987713758 @default.
• W2021525451 cites W1993026821 @default.
• W2021525451 cites W2002051431 @default.
• W2021525451 cites W2004124297 @default.
• W2021525451 cites W2004345869 @default.
• W2021525451 cites W2006281161 @default.
• W2021525451 cites W2008536902 @default.
• W2021525451 cites W2026562513 @default.
• W2021525451 cites W2031141836 @default.
• W2021525451 cites W2031369878 @default.
• W2021525451 cites W2034359690 @default.
• W2021525451 cites W2059412913 @default.
• W2021525451 cites W2072895008 @default.
• W2021525451 cites W2075372159 @default.
• W2021525451 cites W2086121828 @default.
• W2021525451 cites W2091041835 @default.
• W2021525451 cites W2094652659 @default.
• W2021525451 cites W2097844867 @default.
• W2021525451 cites W2097995306 @default.
• W2021525451 cites W2105011122 @default.
• W2021525451 cites W2105139602 @default.
• W2021525451 cites W2118719170 @default.
• W2021525451 cites W2119456915 @default.
• W2021525451 cites W2122554904 @default.
• W2021525451 cites W2122751497 @default.
• W2021525451 cites W2132399579 @default.
• W2021525451 cites W2133997960 @default.
• W2021525451 cites W2135463621 @default.
• W2021525451 cites W2139340015 @default.
• W2021525451 cites W2142170111 @default.
• W2021525451 cites W2142285112 @default.
• W2021525451 cites W2148360952 @default.
• W2021525451 cites W2152876030 @default.
• W2021525451 cites W2153677887 @default.
• W2021525451 cites W2155177282 @default.
• W2021525451 cites W2170704593 @default.
• W2021525451 doi "https://doi.org/10.1158/1078-0432.ccr-10-3328" @default.
• W2021525451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3149850" @default.
• W2021525451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21712448" @default.
• W2021525451 hasPublicationYear "2011" @default.
• W2021525451 type Work @default.
• W2021525451 sameAs 2021525451 @default.
• W2021525451 citedByCount "27" @default.
• W2021525451 countsByYear W20215254512012 @default.
• W2021525451 countsByYear W20215254512013 @default.
• W2021525451 countsByYear W20215254512014 @default.
• W2021525451 countsByYear W20215254512016 @default.
• W2021525451 countsByYear W20215254512017 @default.
• W2021525451 countsByYear W20215254512019 @default.
• W2021525451 countsByYear W20215254512020 @default.
• W2021525451 countsByYear W20215254512021 @default.
• W2021525451 countsByYear W20215254512022 @default.
• W2021525451 countsByYear W20215254512023 @default.
• W2021525451 crossrefType "journal-article" @default.
• W2021525451 hasAuthorship W2021525451A5000555155 @default.
• W2021525451 hasAuthorship W2021525451A5001202734 @default.
• W2021525451 hasAuthorship W2021525451A5001572155 @default.
• W2021525451 hasAuthorship W2021525451A5010776860 @default.
• W2021525451 hasAuthorship W2021525451A5028801725 @default.
• W2021525451 hasAuthorship W2021525451A5032755285 @default.
• W2021525451 hasAuthorship W2021525451A5033608310 @default.
• W2021525451 hasAuthorship W2021525451A5063880073 @default.
• W2021525451 hasAuthorship W2021525451A5087859996 @default.
• W2021525451 hasBestOaLocation W20215254511 @default.
• W2021525451 hasConcept C148125776 @default.
• W2021525451 hasConcept C173396325 @default.
• W2021525451 hasConcept C190283241 @default.
• W2021525451 hasConcept C203014093 @default.
• W2021525451 hasConcept C22615655 @default.
• W2021525451 hasConcept C2776090121 @default.
• W2021525451 hasConcept C2777701055 @default.
• W2021525451 hasConcept C2778690821 @default.

• next