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- W2021526239 abstract "The effects of systemically administered clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal were examined. In naive animals, clonidine (0.5 and 1 mg/kg s.c.) significantly increased plasma β-endorphin-like immunoreactivity (β-END-LI) and cortisol levels. This effect was significantly reduced in morphine-tolerant animals. Naloxone treatment induced an increase of plasma β-END-LI and cortisol levels in morphine-tolerant animals. The increase in cortisol level after withdrawal was significantly reduced by clonidine. These results are consistent with an interaction between α<sub>2</sub>-adrenoceptors and opioid systems in the control of pituitary-adrenocortical axis during morphine tolerance and withdrawal." @default.
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- W2021526239 date "1992-01-01" @default.
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- W2021526239 title "Effects of Clonidine on Pituitary- Adrenocortical Axis in Morphine-Tolerant Rats and after Naloxone-lnduced Withdrawal" @default.
- W2021526239 doi "https://doi.org/10.1159/000138908" @default.
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