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• W2021532914 abstract "Characterisation of 35 Kluyveromyces lactis strains lacking mitochondrial DNA has shown that mutations suppressing ρ0-lethality are limited to the ATP1, 2 and 3 genes coding for the α-, β- and γ- subunits of mitochondrial F1-ATPase. All atp mutations reduce growth on glucose and three alleles, atp1-2, 1-3 and atp3-1, produce a respiratory deficient phenotype that indicates a drop in efficiency of the F1F0-ATP synthase complex. ATPase activity is needed for suppression as a double mutant containing an atp allele, together with a mutation abolishing catalytic activity, does not suppress ρ0-lethality. Positioning of the seven amino acids subject to mutation on the bovine F1-ATPase structure shows that two residues are found in a membrane proximal region while five amino acids occur at a region suggested to be a molecular bearing. The intriguing juxtaposition of mutable amino acids to other residues subject to change suggests that mutations affect subunit interactions and alter the properties of F1 in a manner yet to be determined. An explanation for suppressor activity of atp mutations is discussed in the context of a possible role for F1-ATPase in the maintenance of mitochondrial inner membrane potential." @default.
• W2021532914 created "2016-06-24" @default.
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• W2021532914 date "2000-03-01" @default.
• W2021532914 modified "2023-09-24" @default.
• W2021532914 title "Mutant residues suppressing ρ0-lethality in Kluyveromyces lactis occur at contact sites between subunits of F1-ATPase" @default.
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• W2021532914 doi "https://doi.org/10.1016/s0167-4838(00)00003-0" @default.
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