FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021534461> ?p ?o ?g. }

• W2021534461 endingPage "1634" @default.
• W2021534461 startingPage "1629" @default.
• W2021534461 abstract "The eukaryotic elongation factors (eEF1A2 and eEF1A1) play a key role in translation of messenger RNA (mRNA) to protein. In skeletal muscle of healthy humans, EEF1A2 is overexpressed and selected over EEF1A1. In cellular stress models, muscle EEF1A1 expression increased and was associated with apoptosis and catabolism. We have determined mRNA levels of EEF1A1 and EEF1A2, as well as those of other proapoptotic genes, such as p66(ShcA) and c-MYC, in skeletal muscle of severely traumatized patients and healthy volunteers. Muscle protein kinetic was determined by stable isotopes and the arteriovenous technique. The patients were in a hypercatabolic condition because the rate of muscle proteolysis exceeded that of synthesis. Mean mRNA levels of EEF1A1 and EEF1A2 were 165- and 29-fold greater (P < .01) in patients than in the control group, respectively. Mean p66(ShcA) mRNA levels were 3-fold greater (P < .05) in patients than in the controls. In contrast, c-MYC mRNA levels were not significantly different in patients and healthy controls. In patients, muscle mRNA levels of EEF1A1 and p66(ShcA) directly correlated (P < .05) with the rate of proteolysis (R = 0.901 and R = 0.826, respectively). This is in agreement with a reduction in actin and tubulin protein content, both markers of cytoskeletal and sarcomeric disorganization, and with an increased poly(adenosine diphosphate-ribose) polymerase cleavage, a marker of apoptosis. In conclusion, in hypercatabolic traumatized patients, an up-regulation of muscle EEF1A1 and p66(ShcA) relates to proteolysis rate, suggesting an involvement of these genes in muscle catabolic response." @default.
• W2021534461 created "2016-06-24" @default.
• W2021534461 creator A5005867837 @default.
• W2021534461 creator A5013649375 @default.
• W2021534461 creator A5040625595 @default.
• W2021534461 creator A5081926215 @default.
• W2021534461 creator A5086417559 @default.
• W2021534461 date "2007-12-01" @default.
• W2021534461 modified "2023-09-30" @default.
• W2021534461 title "Overexpression of the elongation factor 1A1 relates to muscle proteolysis and proapoptotic p66(ShcA) gene transcription in hypercatabolic trauma patients" @default.
• W2021534461 cites W1484492220 @default.
• W2021534461 cites W1522341023 @default.
• W2021534461 cites W1560901632 @default.
• W2021534461 cites W1898589556 @default.
• W2021534461 cites W1956418669 @default.
• W2021534461 cites W1971637469 @default.
• W2021534461 cites W1974003656 @default.
• W2021534461 cites W1981779788 @default.
• W2021534461 cites W2013504815 @default.
• W2021534461 cites W201387235 @default.
• W2021534461 cites W2023706819 @default.
• W2021534461 cites W2024544617 @default.
• W2021534461 cites W2025327921 @default.
• W2021534461 cites W2040225557 @default.
• W2021534461 cites W2045113803 @default.
• W2021534461 cites W2045799753 @default.
• W2021534461 cites W2057382120 @default.
• W2021534461 cites W2058767200 @default.
• W2021534461 cites W2059169851 @default.
• W2021534461 cites W2066446604 @default.
• W2021534461 cites W2069537586 @default.
• W2021534461 cites W2071088250 @default.
• W2021534461 cites W2075540776 @default.
• W2021534461 cites W2087487742 @default.
• W2021534461 cites W2089735593 @default.
• W2021534461 cites W2097774235 @default.
• W2021534461 cites W2098787491 @default.
• W2021534461 cites W2106612017 @default.
• W2021534461 cites W2110098472 @default.
• W2021534461 cites W2112544744 @default.
• W2021534461 cites W2122696263 @default.
• W2021534461 cites W2133959230 @default.
• W2021534461 cites W2149060516 @default.
• W2021534461 cites W2154584639 @default.
• W2021534461 cites W2157405979 @default.
• W2021534461 cites W4255478452 @default.
• W2021534461 cites W70664813 @default.
• W2021534461 doi "https://doi.org/10.1016/j.metabol.2007.07.003" @default.
• W2021534461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17998013" @default.
• W2021534461 hasPublicationYear "2007" @default.
• W2021534461 type Work @default.
• W2021534461 sameAs 2021534461 @default.
• W2021534461 citedByCount "13" @default.
• W2021534461 countsByYear W20215344612013 @default.
• W2021534461 countsByYear W20215344612015 @default.
• W2021534461 countsByYear W20215344612019 @default.
• W2021534461 countsByYear W20215344612020 @default.
• W2021534461 countsByYear W20215344612022 @default.
• W2021534461 crossrefType "journal-article" @default.
• W2021534461 hasAuthorship W2021534461A5005867837 @default.
• W2021534461 hasAuthorship W2021534461A5013649375 @default.
• W2021534461 hasAuthorship W2021534461A5040625595 @default.
• W2021534461 hasAuthorship W2021534461A5081926215 @default.
• W2021534461 hasAuthorship W2021534461A5086417559 @default.
• W2021534461 hasConcept C104317684 @default.
• W2021534461 hasConcept C105580179 @default.
• W2021534461 hasConcept C126322002 @default.
• W2021534461 hasConcept C134018914 @default.
• W2021534461 hasConcept C150194340 @default.
• W2021534461 hasConcept C181199279 @default.
• W2021534461 hasConcept C2779959927 @default.
• W2021534461 hasConcept C2781307694 @default.
• W2021534461 hasConcept C55493867 @default.
• W2021534461 hasConcept C67705224 @default.
• W2021534461 hasConcept C71924100 @default.
• W2021534461 hasConcept C75186080 @default.
• W2021534461 hasConcept C86803240 @default.
• W2021534461 hasConcept C88478588 @default.
• W2021534461 hasConceptScore W2021534461C104317684 @default.
• W2021534461 hasConceptScore W2021534461C105580179 @default.
• W2021534461 hasConceptScore W2021534461C126322002 @default.
• W2021534461 hasConceptScore W2021534461C134018914 @default.
• W2021534461 hasConceptScore W2021534461C150194340 @default.
• W2021534461 hasConceptScore W2021534461C181199279 @default.
• W2021534461 hasConceptScore W2021534461C2779959927 @default.
• W2021534461 hasConceptScore W2021534461C2781307694 @default.
• W2021534461 hasConceptScore W2021534461C55493867 @default.
• W2021534461 hasConceptScore W2021534461C67705224 @default.
• W2021534461 hasConceptScore W2021534461C71924100 @default.
• W2021534461 hasConceptScore W2021534461C75186080 @default.
• W2021534461 hasConceptScore W2021534461C86803240 @default.
• W2021534461 hasConceptScore W2021534461C88478588 @default.
• W2021534461 hasIssue "12" @default.
• W2021534461 hasLocation W20215344611 @default.
• W2021534461 hasLocation W20215344612 @default.
• W2021534461 hasOpenAccess W2021534461 @default.
• W2021534461 hasPrimaryLocation W20215344611 @default.
• W2021534461 hasRelatedWork W1974568996 @default.

• next