FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021537592> ?p ?o ?g. }

• W2021537592 endingPage "4497" @default.
• W2021537592 startingPage "4490" @default.
• W2021537592 abstract "A recombinant, catalytically inactive Clostridium botulinum neurotoxin A1 holoprotein (ciBoNT/A1 HP) was constructed by introducing amino acid substitutions H223A, E224A, and H227A in the active site to ablate proteolytic activity. ciBoNT/A1 HP was produced in the yeast Pichia pastoris and the purified product was evaluated as a vaccine candidate by comparison against recombinant BoNT/A1 LC, LC-belt, LC-Hn, and Hc antigens and a LC-Hn + Hc combination in mouse potency and efficacy bioassays when challenged with BoNT/A subtypes /A1, /A2, and /A3. A single dose of ciBoNT/A1 HP provided equivalent or greater protective immunity, not only against the homologous toxin, but also against two distinct toxin subtypes with significant amino acid divergence. Only the LC-Hn + Hc combination provided comparable protection against /A1; however, it was less effective against subtypes /A2 and /A3. Differences in protective immunity diminished after multiple vaccinations with either ciBoNT/A1 HP or BoNT/A1 Hc, and the survival rates were more comparable at the toxin levels used to challenge." @default.
• W2021537592 created "2016-06-24" @default.
• W2021537592 creator A5032466026 @default.
• W2021537592 creator A5038922080 @default.
• W2021537592 creator A5046226741 @default.
• W2021537592 creator A5053226584 @default.
• W2021537592 creator A5085136688 @default.
• W2021537592 date "2009-07-01" @default.
• W2021537592 modified "2023-09-28" @default.
• W2021537592 title "Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3" @default.
• W2021537592 cites W1543585694 @default.
• W2021537592 cites W1973061735 @default.
• W2021537592 cites W1974845496 @default.
• W2021537592 cites W1988078730 @default.
• W2021537592 cites W1997999104 @default.
• W2021537592 cites W2007982098 @default.
• W2021537592 cites W2011227278 @default.
• W2021537592 cites W2027872729 @default.
• W2021537592 cites W2036059965 @default.
• W2021537592 cites W2039201478 @default.
• W2021537592 cites W2041306698 @default.
• W2021537592 cites W2045061466 @default.
• W2021537592 cites W2054487167 @default.
• W2021537592 cites W2054806862 @default.
• W2021537592 cites W2061604407 @default.
• W2021537592 cites W2068277564 @default.
• W2021537592 cites W2070155290 @default.
• W2021537592 cites W2076322767 @default.
• W2021537592 cites W2081769761 @default.
• W2021537592 cites W2090106870 @default.
• W2021537592 cites W2099635745 @default.
• W2021537592 cites W2113569765 @default.
• W2021537592 cites W2118154806 @default.
• W2021537592 cites W2122977798 @default.
• W2021537592 cites W2124190300 @default.
• W2021537592 cites W2126444066 @default.
• W2021537592 cites W2127161099 @default.
• W2021537592 cites W2158406618 @default.
• W2021537592 cites W2163264253 @default.
• W2021537592 cites W2172115284 @default.
• W2021537592 cites W228613302 @default.
• W2021537592 cites W4241019103 @default.
• W2021537592 doi "https://doi.org/10.1016/j.vaccine.2009.05.030" @default.
• W2021537592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19450643" @default.
• W2021537592 hasPublicationYear "2009" @default.
• W2021537592 type Work @default.
• W2021537592 sameAs 2021537592 @default.
• W2021537592 citedByCount "55" @default.
• W2021537592 countsByYear W20215375922012 @default.
• W2021537592 countsByYear W20215375922013 @default.
• W2021537592 countsByYear W20215375922014 @default.
• W2021537592 countsByYear W20215375922015 @default.
• W2021537592 countsByYear W20215375922016 @default.
• W2021537592 countsByYear W20215375922017 @default.
• W2021537592 countsByYear W20215375922018 @default.
• W2021537592 countsByYear W20215375922020 @default.
• W2021537592 countsByYear W20215375922021 @default.
• W2021537592 countsByYear W20215375922022 @default.
• W2021537592 countsByYear W20215375922023 @default.
• W2021537592 crossrefType "journal-article" @default.
• W2021537592 hasAuthorship W2021537592A5032466026 @default.
• W2021537592 hasAuthorship W2021537592A5038922080 @default.
• W2021537592 hasAuthorship W2021537592A5046226741 @default.
• W2021537592 hasAuthorship W2021537592A5053226584 @default.
• W2021537592 hasAuthorship W2021537592A5085136688 @default.
• W2021537592 hasConcept C104292427 @default.
• W2021537592 hasConcept C104317684 @default.
• W2021537592 hasConcept C153911025 @default.
• W2021537592 hasConcept C159047783 @default.
• W2021537592 hasConcept C185592680 @default.
• W2021537592 hasConcept C2777010668 @default.
• W2021537592 hasConcept C2777367657 @default.
• W2021537592 hasConcept C2781372317 @default.
• W2021537592 hasConcept C40767141 @default.
• W2021537592 hasConcept C515207424 @default.
• W2021537592 hasConcept C55493867 @default.
• W2021537592 hasConcept C86803240 @default.
• W2021537592 hasConcept C89423630 @default.
• W2021537592 hasConceptScore W2021537592C104292427 @default.
• W2021537592 hasConceptScore W2021537592C104317684 @default.
• W2021537592 hasConceptScore W2021537592C153911025 @default.
• W2021537592 hasConceptScore W2021537592C159047783 @default.
• W2021537592 hasConceptScore W2021537592C185592680 @default.
• W2021537592 hasConceptScore W2021537592C2777010668 @default.
• W2021537592 hasConceptScore W2021537592C2777367657 @default.
• W2021537592 hasConceptScore W2021537592C2781372317 @default.
• W2021537592 hasConceptScore W2021537592C40767141 @default.
• W2021537592 hasConceptScore W2021537592C515207424 @default.
• W2021537592 hasConceptScore W2021537592C55493867 @default.
• W2021537592 hasConceptScore W2021537592C86803240 @default.
• W2021537592 hasConceptScore W2021537592C89423630 @default.
• W2021537592 hasIssue "33" @default.
• W2021537592 hasLocation W20215375921 @default.
• W2021537592 hasLocation W20215375922 @default.
• W2021537592 hasOpenAccess W2021537592 @default.
• W2021537592 hasPrimaryLocation W20215375921 @default.
• W2021537592 hasRelatedWork W1696096160 @default.
• W2021537592 hasRelatedWork W2348150867 @default.

• next