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• W2021541861 abstract "ABSTRACT Escherichia coli AraC is a well-described transcription activator of genes involved in arabinose metabolism. Using complementary genomic approaches, chromatin immunoprecipitation (ChIP)-chip, and transcription profiling, we identify direct regulatory targets of AraC, including five novel target genes: ytfQ , ydeN , ydeM , ygeA , and polB . Strikingly, only ytfQ has an established connection to arabinose metabolism, suggesting that AraC has a broader function than previously described. We demonstrate arabinose-dependent repression of ydeNM by AraC, in contrast to the well-described arabinose-dependent activation of other target genes. We also demonstrate unexpected read-through of transcription at the Rho-independent terminators downstream of araD and araE , leading to significant increases in the expression of polB and ygeA , respectively. AraC is highly conserved in the related species Salmonella enterica . We use ChIP sequencing (ChIP-seq) and RNA sequencing (RNA-seq) to map the AraC regulon in S. enterica . A comparison of the E. coli and S. enterica AraC regulons, coupled with a bioinformatic analysis of other related species, reveals a conserved regulatory network across the family Enterobacteriaceae comprised of 10 genes associated with arabinose transport and metabolism." @default.
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• W2021541861 date "2014-02-01" @default.
• W2021541861 modified "2023-10-14" @default.
• W2021541861 title "Genome-Scale Analyses of Escherichia coli and Salmonella enterica AraC Reveal Noncanonical Targets and an Expanded Core Regulon" @default.
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• W2021541861 doi "https://doi.org/10.1128/jb.01007-13" @default.
• W2021541861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3911152" @default.
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