FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021546768> ?p ?o ?g. }

• W2021546768 endingPage "314" @default.
• W2021546768 startingPage "305" @default.
• W2021546768 abstract "<i>Background:</i> Shellfish hypersensitivity is amongst the most common food allergies. The major shellfish allergen was identified as tropomyosin. Here, we investigated the immediate hypersensitivity responses, IgE and cell-mediated immune response in mice sensitized with recombinant shrimp tropomyosin. <i>Methods:</i> Shrimp tropomyosin was cloned and expressed as a His-tagged fusion recombinant protein in <i>Escherichia coli. </i>Three- to 4-week-old BALB/c mice were sensitized by intragastric administration of recombinant tropomyosin (0.1 mg) plus cholera toxin (10 µg) on days 0, 12, 19 and 26 and challenged on day 33. Mice fed with phosphate-buffered saline plus cholera toxin were included as controls. Animals were monitored for immediate hypersensitive responses and tropomyosin-specific IgE over time. In addition, shrimp tropomyosin-specific CD4+ T cells, interleukin-4 and interferon-γ levels were determined from in vitro splenocyte cultures. A passive cutaneous anaphylaxis assay was also conducted. <i>Results:</i> Mice fed with shrimp tropomyosin developed swelling of the snout, increased scratching behavior and shrimp tropomyosin-specific IgE. Sera from tropomyosin-sensitized mice elicited vascular leakage in naïve mice in the passive cutaneous anaphylaxis assay. Shrimp tropomyosin-specific CD4+ T cell proliferations and elevated interleukin-4 over interferon-γ levels were evident in splenocyte cultures of tropomyosin-fed mice upon tropomyosin stimulation. In contrast, shrimp tropomyosin-specific IgE, CD4+ T cells and hypersensitive responses were absent in the control mice. <i>Conclusion:</i> We have generated a BALB/c model of shrimp allergy. This model provides a useful tool for evaluating the immunopathogenic mechanisms involved in shellfish hypersensitivity." @default.
• W2021546768 created "2016-06-24" @default.
• W2021546768 creator A5003532193 @default.
• W2021546768 creator A5008596479 @default.
• W2021546768 creator A5013804183 @default.
• W2021546768 creator A5016117800 @default.
• W2021546768 creator A5016339066 @default.
• W2021546768 creator A5016645912 @default.
• W2021546768 creator A5062741168 @default.
• W2021546768 creator A5084393254 @default.
• W2021546768 date "2008-01-01" @default.
• W2021546768 modified "2023-10-18" @default.
• W2021546768 title "Induction of Shrimp Tropomyosin-Specific Hypersensitivity in Mice" @default.
• W2021546768 cites W139025221 @default.
• W2021546768 cites W1562907767 @default.
• W2021546768 cites W1575553666 @default.
• W2021546768 cites W1783384839 @default.
• W2021546768 cites W1967035013 @default.
• W2021546768 cites W1967925144 @default.
• W2021546768 cites W1973846182 @default.
• W2021546768 cites W1978223939 @default.
• W2021546768 cites W1979049360 @default.
• W2021546768 cites W1980903421 @default.
• W2021546768 cites W1983749274 @default.
• W2021546768 cites W1987102811 @default.
• W2021546768 cites W1987494349 @default.
• W2021546768 cites W1991594419 @default.
• W2021546768 cites W2002072394 @default.
• W2021546768 cites W2013141036 @default.
• W2021546768 cites W2014730134 @default.
• W2021546768 cites W2023610121 @default.
• W2021546768 cites W2024378901 @default.
• W2021546768 cites W2030014527 @default.
• W2021546768 cites W2033131809 @default.
• W2021546768 cites W2050876364 @default.
• W2021546768 cites W2056201830 @default.
• W2021546768 cites W2058951284 @default.
• W2021546768 cites W2063380886 @default.
• W2021546768 cites W2070330822 @default.
• W2021546768 cites W2071244293 @default.
• W2021546768 cites W2073245320 @default.
• W2021546768 cites W2089383541 @default.
• W2021546768 cites W2091882145 @default.
• W2021546768 cites W2092359331 @default.
• W2021546768 cites W2099509454 @default.
• W2021546768 cites W2100183318 @default.
• W2021546768 cites W2103127771 @default.
• W2021546768 cites W2103826062 @default.
• W2021546768 cites W2104304199 @default.
• W2021546768 cites W2112866067 @default.
• W2021546768 cites W2114941528 @default.
• W2021546768 cites W2122176553 @default.
• W2021546768 cites W2124885315 @default.
• W2021546768 cites W2125906940 @default.
• W2021546768 cites W2142647990 @default.
• W2021546768 cites W2144368594 @default.
• W2021546768 cites W2151966368 @default.
• W2021546768 cites W2152474063 @default.
• W2021546768 cites W2152511008 @default.
• W2021546768 cites W2159358866 @default.
• W2021546768 cites W2415666028 @default.
• W2021546768 cites W2417746652 @default.
• W2021546768 cites W2463783982 @default.
• W2021546768 cites W2771161702 @default.
• W2021546768 doi "https://doi.org/10.1159/000144038" @default.
• W2021546768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18617750" @default.
• W2021546768 hasPublicationYear "2008" @default.
• W2021546768 type Work @default.
• W2021546768 sameAs 2021546768 @default.
• W2021546768 citedByCount "27" @default.
• W2021546768 countsByYear W20215467682012 @default.
• W2021546768 countsByYear W20215467682013 @default.
• W2021546768 countsByYear W20215467682014 @default.
• W2021546768 countsByYear W20215467682015 @default.
• W2021546768 countsByYear W20215467682016 @default.
• W2021546768 countsByYear W20215467682017 @default.
• W2021546768 countsByYear W20215467682018 @default.
• W2021546768 countsByYear W20215467682019 @default.
• W2021546768 countsByYear W20215467682020 @default.
• W2021546768 countsByYear W20215467682021 @default.
• W2021546768 countsByYear W20215467682022 @default.
• W2021546768 countsByYear W20215467682023 @default.
• W2021546768 crossrefType "journal-article" @default.
• W2021546768 hasAuthorship W2021546768A5003532193 @default.
• W2021546768 hasAuthorship W2021546768A5008596479 @default.
• W2021546768 hasAuthorship W2021546768A5013804183 @default.
• W2021546768 hasAuthorship W2021546768A5016117800 @default.
• W2021546768 hasAuthorship W2021546768A5016339066 @default.
• W2021546768 hasAuthorship W2021546768A5016645912 @default.
• W2021546768 hasAuthorship W2021546768A5062741168 @default.
• W2021546768 hasAuthorship W2021546768A5084393254 @default.
• W2021546768 hasConcept C141105273 @default.
• W2021546768 hasConcept C153911025 @default.
• W2021546768 hasConcept C159654299 @default.
• W2021546768 hasConcept C189976730 @default.
• W2021546768 hasConcept C203014093 @default.
• W2021546768 hasConcept C205875245 @default.
• W2021546768 hasConcept C207480886 @default.

• next