Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021550176> ?p ?o ?g. }
- W2021550176 endingPage "1218" @default.
- W2021550176 startingPage "1211" @default.
- W2021550176 abstract "The human multidrug resistance-associated protein MRP confers resistance to various cytotoxic drugs by lowering the intracellular drug concentration. Recent evidence indicates that MRP can also transport glutathione S-conjugates across membranes. To study the transport properties of MRP in intact cells, we have expressed human MRP cDNA in the polarized pig kidney epithelial cell line LLC-PK1. MRP mainly localized to the basolateral plasma membrane of these cells, and not to the apical membrane, as determined by immunocytochemistry using confocal laser scanning and electron microscopy. In accordance with this localization, MRP caused increased transport of the glutathione S-conjugate S-(2, 4-dinitrophenyl)-glutathione and of the anticancer drug daunorubicin to the basal side of the epithelial cell layer. Sulfinpyrazone and probenecid, known inhibitors of multispecific organic anion transport, inhibited this basolateral transport, but not the apical transport of daunorubicin mediated by the apically localized human MDR1 P-glycoprotein in MDR1-transfected LLC-PK1 cells. Probenecid and sulfinpyrazone may therefore be useful lead compounds for the development of clinical reversal agents specific for MRP-mediated drug resistance." @default.
- W2021550176 created "2016-06-24" @default.
- W2021550176 creator A5042002328 @default.
- W2021550176 creator A5044314042 @default.
- W2021550176 creator A5045217576 @default.
- W2021550176 creator A5056249795 @default.
- W2021550176 creator A5058054208 @default.
- W2021550176 creator A5060054431 @default.
- W2021550176 creator A5062340815 @default.
- W2021550176 creator A5063187405 @default.
- W2021550176 creator A5064222916 @default.
- W2021550176 date "1996-03-01" @default.
- W2021550176 modified "2023-10-09" @default.
- W2021550176 title "Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells." @default.
- W2021550176 cites W1502426706 @default.
- W2021550176 cites W1526872663 @default.
- W2021550176 cites W1647833960 @default.
- W2021550176 cites W1823445908 @default.
- W2021550176 cites W1964470226 @default.
- W2021550176 cites W1965372133 @default.
- W2021550176 cites W1972977050 @default.
- W2021550176 cites W1983548371 @default.
- W2021550176 cites W2006322123 @default.
- W2021550176 cites W2012841076 @default.
- W2021550176 cites W2030763326 @default.
- W2021550176 cites W2062401742 @default.
- W2021550176 cites W2067898376 @default.
- W2021550176 cites W2076536269 @default.
- W2021550176 cites W2078998991 @default.
- W2021550176 cites W2093601519 @default.
- W2021550176 cites W2098858652 @default.
- W2021550176 cites W2112001901 @default.
- W2021550176 cites W2118234018 @default.
- W2021550176 cites W2127819051 @default.
- W2021550176 cites W2136564762 @default.
- W2021550176 cites W2138792907 @default.
- W2021550176 cites W2141428099 @default.
- W2021550176 cites W2143862282 @default.
- W2021550176 cites W2152117655 @default.
- W2021550176 cites W2164093006 @default.
- W2021550176 cites W2168070336 @default.
- W2021550176 cites W2168095256 @default.
- W2021550176 cites W2170385301 @default.
- W2021550176 cites W243604420 @default.
- W2021550176 cites W2470478537 @default.
- W2021550176 doi "https://doi.org/10.1172/jci118535" @default.
- W2021550176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507173" @default.
- W2021550176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8636432" @default.
- W2021550176 hasPublicationYear "1996" @default.
- W2021550176 type Work @default.
- W2021550176 sameAs 2021550176 @default.
- W2021550176 citedByCount "249" @default.
- W2021550176 countsByYear W20215501762012 @default.
- W2021550176 countsByYear W20215501762013 @default.
- W2021550176 countsByYear W20215501762014 @default.
- W2021550176 countsByYear W20215501762015 @default.
- W2021550176 countsByYear W20215501762016 @default.
- W2021550176 countsByYear W20215501762017 @default.
- W2021550176 countsByYear W20215501762018 @default.
- W2021550176 countsByYear W20215501762021 @default.
- W2021550176 countsByYear W20215501762022 @default.
- W2021550176 countsByYear W20215501762023 @default.
- W2021550176 crossrefType "journal-article" @default.
- W2021550176 hasAuthorship W2021550176A5042002328 @default.
- W2021550176 hasAuthorship W2021550176A5044314042 @default.
- W2021550176 hasAuthorship W2021550176A5045217576 @default.
- W2021550176 hasAuthorship W2021550176A5056249795 @default.
- W2021550176 hasAuthorship W2021550176A5058054208 @default.
- W2021550176 hasAuthorship W2021550176A5060054431 @default.
- W2021550176 hasAuthorship W2021550176A5062340815 @default.
- W2021550176 hasAuthorship W2021550176A5063187405 @default.
- W2021550176 hasAuthorship W2021550176A5064222916 @default.
- W2021550176 hasBestOaLocation W20215501761 @default.
- W2021550176 hasConcept C104317684 @default.
- W2021550176 hasConcept C133936738 @default.
- W2021550176 hasConcept C149011108 @default.
- W2021550176 hasConcept C1491633281 @default.
- W2021550176 hasConcept C181199279 @default.
- W2021550176 hasConcept C185592680 @default.
- W2021550176 hasConcept C203014093 @default.
- W2021550176 hasConcept C2776769776 @default.
- W2021550176 hasConcept C2778461978 @default.
- W2021550176 hasConcept C2778707650 @default.
- W2021550176 hasConcept C2781021840 @default.
- W2021550176 hasConcept C2910769707 @default.
- W2021550176 hasConcept C3018436504 @default.
- W2021550176 hasConcept C39587587 @default.
- W2021550176 hasConcept C41625074 @default.
- W2021550176 hasConcept C44312359 @default.
- W2021550176 hasConcept C501593827 @default.
- W2021550176 hasConcept C538909803 @default.
- W2021550176 hasConcept C54355233 @default.
- W2021550176 hasConcept C55493867 @default.
- W2021550176 hasConcept C57581600 @default.
- W2021550176 hasConcept C57947595 @default.
- W2021550176 hasConcept C79879829 @default.
- W2021550176 hasConcept C81885089 @default.
- W2021550176 hasConcept C86803240 @default.