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- W2021554230 abstract "The in vitro activity of piperacillin alone or titrated with a constant concentration of 4 μg/ml tazobactam was evaluated against 3962 baseline pathogens isolated from 1899 patients enrolled in 9 clinical trial studies in North America. Tazobactam increased susceptibility rates of piperacillin for Enterobacteriaceae from 81% to 96%, Staphylococcus (methicillin susceptible) spp. from 6% to 100%, Bacteroides fragilis group from 79% to >99% and Haemophilus from 85% to 98%. The excellent activity of piperacillin against Pseudomonas, Streptococcus and Enterococcus was maintained in the presence of tazobactam. Overall piperacillin/tazobactam had better activity than ticarcillin/clavulanic acid, ceftazidime, and in general equaled the activity of imipenem. The excellent in vitro, extended-spectrum activity of piperacillin/tazobactam suggests its utility for various infections." @default.
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- W2021554230 date "1996-05-01" @default.
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- W2021554230 title "In vitro activity of piperacillin/tazobactam against isolates from patients enrolled in clinical trials" @default.
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- W2021554230 doi "https://doi.org/10.1016/0924-8579(96)00004-0" @default.
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