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• W2021557579 abstract "A new epitetrathiodioxopiperizine, secoemestrin D (1), and five sesterterpenoids bearing a new carbon skeleton, emericellenes A–E (2–6), together with previously known fungal metabolites, sterigmatocystin (7), arugosin C (8), and epiisoshamixanthone (9), were obtained from the endophytic fungal strain Emericella sp. AST0036 isolated from a healthy leaf tissue of Astragalus lentiginosus. The planar structures and relative configurations of the new metabolites 1–6 were elucidated using MS and 1D and 2D NMR spectroscopic data. All compounds were evaluated for their potential anticancer activity using a panel of six tumor cell lines and normal human fibroblast cells. Only metabolites 1 and 7 showed cytotoxic activity. More importantly, secoemestrin D (1) exhibited significant cytotoxicity with IC50 values ranging from 0.06 to 0.24 μM and moderate selectivity to human glioma (SF-268) and metastatic breast adenocarcinoma (MDA-MB-231) cell lines." @default.
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• W2021557579 date "2013-11-19" @default.
• W2021557579 modified "2023-10-16" @default.
• W2021557579 title "Secoemestrin D, a Cytotoxic Epitetrathiodioxopiperizine, and Emericellenes A–E, Five Sesterterpenoids from <i>Emericella</i> sp. AST0036, a Fungal Endophyte of <i>Astragalus lentiginosus</i>1" @default.
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• W2021557579 doi "https://doi.org/10.1021/np400762k" @default.
• W2021557579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3946369" @default.
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