Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021567419> ?p ?o ?g. }
- W2021567419 endingPage "e111573" @default.
- W2021567419 startingPage "e111573" @default.
- W2021567419 abstract "Morphogens are signaling molecules that regulate growth and patterning during development by forming a gradient and activating different target genes at different concentrations. The extracellular distribution of morphogens is tightly regulated, with the Drosophila morphogen Wingless (Wg) relying on Dally-like (Dlp) and transcytosis for its distribution. However, in the absence of Dlp or endocytic activity, Wg can still move across cells along the apical (Ap) surface. We identified a novel secreted heparan sulfate proteoglycan (HSPG) that binds to Wg and promotes its extracellular distribution by increasing Wg mobility, which was thus named Carrier of Wg (Cow). Cow promotes the Ap transport of Wg, independent of Dlp and endocytosis, and this function addresses a previous gap in the understanding of Wg movement. This is the first example of a diffusible HSPG acting as a carrier to promote the extracellular movement of a morphogen." @default.
- W2021567419 created "2016-06-24" @default.
- W2021567419 creator A5001247532 @default.
- W2021567419 creator A5067668992 @default.
- W2021567419 date "2014-10-31" @default.
- W2021567419 modified "2023-10-16" @default.
- W2021567419 title "Carrier of Wingless (Cow), a Secreted Heparan Sulfate Proteoglycan, Promotes Extracellular Transport of Wingless" @default.
- W2021567419 cites W1507573241 @default.
- W2021567419 cites W1536888683 @default.
- W2021567419 cites W1723090406 @default.
- W2021567419 cites W1819149160 @default.
- W2021567419 cites W1911201077 @default.
- W2021567419 cites W1938204331 @default.
- W2021567419 cites W1965558704 @default.
- W2021567419 cites W1971085650 @default.
- W2021567419 cites W1971665331 @default.
- W2021567419 cites W1975420952 @default.
- W2021567419 cites W1975595193 @default.
- W2021567419 cites W1988532857 @default.
- W2021567419 cites W1989117766 @default.
- W2021567419 cites W1993827187 @default.
- W2021567419 cites W2000426924 @default.
- W2021567419 cites W2003241066 @default.
- W2021567419 cites W2006419043 @default.
- W2021567419 cites W2010479131 @default.
- W2021567419 cites W2013932533 @default.
- W2021567419 cites W2013986963 @default.
- W2021567419 cites W2017269341 @default.
- W2021567419 cites W2025453970 @default.
- W2021567419 cites W2026377725 @default.
- W2021567419 cites W2029042594 @default.
- W2021567419 cites W2029307548 @default.
- W2021567419 cites W2029330897 @default.
- W2021567419 cites W2039313867 @default.
- W2021567419 cites W2039806395 @default.
- W2021567419 cites W2045655335 @default.
- W2021567419 cites W2046442794 @default.
- W2021567419 cites W2046970439 @default.
- W2021567419 cites W2049328469 @default.
- W2021567419 cites W2054600993 @default.
- W2021567419 cites W2060381864 @default.
- W2021567419 cites W2062758922 @default.
- W2021567419 cites W2067937471 @default.
- W2021567419 cites W2068505185 @default.
- W2021567419 cites W2076324043 @default.
- W2021567419 cites W2078519210 @default.
- W2021567419 cites W2085204257 @default.
- W2021567419 cites W2085730270 @default.
- W2021567419 cites W2086209077 @default.
- W2021567419 cites W2086540936 @default.
- W2021567419 cites W2092620853 @default.
- W2021567419 cites W2093455697 @default.
- W2021567419 cites W2093957890 @default.
- W2021567419 cites W2098357545 @default.
- W2021567419 cites W2108345995 @default.
- W2021567419 cites W2110643873 @default.
- W2021567419 cites W2112038940 @default.
- W2021567419 cites W2115330624 @default.
- W2021567419 cites W2124955351 @default.
- W2021567419 cites W2126536695 @default.
- W2021567419 cites W2136576944 @default.
- W2021567419 cites W2141957520 @default.
- W2021567419 cites W2143366342 @default.
- W2021567419 cites W2146150648 @default.
- W2021567419 cites W2147666645 @default.
- W2021567419 cites W2151041036 @default.
- W2021567419 cites W2152567646 @default.
- W2021567419 cites W2155592738 @default.
- W2021567419 cites W2157486530 @default.
- W2021567419 cites W2158682440 @default.
- W2021567419 cites W2167364244 @default.
- W2021567419 cites W2168149321 @default.
- W2021567419 cites W2186370879 @default.
- W2021567419 cites W321588607 @default.
- W2021567419 cites W4214911971 @default.
- W2021567419 doi "https://doi.org/10.1371/journal.pone.0111573" @default.
- W2021567419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4216105" @default.
- W2021567419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25360738" @default.
- W2021567419 hasPublicationYear "2014" @default.
- W2021567419 type Work @default.
- W2021567419 sameAs 2021567419 @default.
- W2021567419 citedByCount "22" @default.
- W2021567419 countsByYear W20215674192016 @default.
- W2021567419 countsByYear W20215674192017 @default.
- W2021567419 countsByYear W20215674192018 @default.
- W2021567419 countsByYear W20215674192019 @default.
- W2021567419 countsByYear W20215674192020 @default.
- W2021567419 countsByYear W20215674192021 @default.
- W2021567419 countsByYear W20215674192022 @default.
- W2021567419 countsByYear W20215674192023 @default.
- W2021567419 crossrefType "journal-article" @default.
- W2021567419 hasAuthorship W2021567419A5001247532 @default.
- W2021567419 hasAuthorship W2021567419A5067668992 @default.
- W2021567419 hasBestOaLocation W20215674191 @default.
- W2021567419 hasConcept C104317684 @default.
- W2021567419 hasConcept C153074725 @default.
- W2021567419 hasConcept C170493617 @default.
- W2021567419 hasConcept C185350488 @default.