Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021586444> ?p ?o ?g. }
- W2021586444 endingPage "229" @default.
- W2021586444 startingPage "219" @default.
- W2021586444 abstract "Abstract Hydrogels are three‐dimensional networks of crosslinked hydrophilic polymers widely used for protein delivery and tissue engineering. To be eligible for in vivo applications, the hydrogels should not evoke an adverse tissue response. In this study the angiogenic and inflammatory responses in vivo after implantation of photopolymerized thermosensitive poly(hydroxypropyl methacrylamide lactate)‐poly(ethyl copolymer hydrogels are investigated. Hydrogels consisting of polymers with different crosslink densities were subcutaneously implanted in Balb/c mice and histological evaluation of the tissue response was performed. The implants showed an acute and localized inflammatory reaction upon implantation, mainly characterized by a strong infiltration of granulocytes. The acute inflammatory reaction was followed by a milder chronic inflammation which was characterized by infiltration of macrophages and persistent but decreasing levels of granulocytes. The number of macrophages and blood vessels was associated with the biodegradation and resorption of the biomaterial and increased in time as the degradation of the materials progressed. The observed degradation rates in vivo correlated well with previously observed in vitro degradation rates, which suggests that hydrolysis is the main mechanism governing the degradation. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011." @default.
- W2021586444 created "2016-06-24" @default.
- W2021586444 creator A5017735982 @default.
- W2021586444 creator A5025687324 @default.
- W2021586444 creator A5031487758 @default.
- W2021586444 creator A5037434090 @default.
- W2021586444 creator A5051906887 @default.
- W2021586444 creator A5071144290 @default.
- W2021586444 creator A5073473654 @default.
- W2021586444 creator A5091404674 @default.
- W2021586444 date "2011-03-25" @default.
- W2021586444 modified "2023-10-18" @default.
- W2021586444 title "The tissue response to photopolymerized PEG-p(HPMAm-lactate)-based hydrogels" @default.
- W2021586444 cites W1245876582 @default.
- W2021586444 cites W124715329 @default.
- W2021586444 cites W1800156099 @default.
- W2021586444 cites W1963595333 @default.
- W2021586444 cites W1965779501 @default.
- W2021586444 cites W1969136202 @default.
- W2021586444 cites W1970644492 @default.
- W2021586444 cites W1986023680 @default.
- W2021586444 cites W1993494015 @default.
- W2021586444 cites W1995063875 @default.
- W2021586444 cites W1996464607 @default.
- W2021586444 cites W1997801350 @default.
- W2021586444 cites W1999182113 @default.
- W2021586444 cites W2001909877 @default.
- W2021586444 cites W2003049491 @default.
- W2021586444 cites W2003474988 @default.
- W2021586444 cites W2021516665 @default.
- W2021586444 cites W2022558097 @default.
- W2021586444 cites W2025434419 @default.
- W2021586444 cites W2030557341 @default.
- W2021586444 cites W2031350269 @default.
- W2021586444 cites W2036532945 @default.
- W2021586444 cites W2042948347 @default.
- W2021586444 cites W2049941759 @default.
- W2021586444 cites W2050163391 @default.
- W2021586444 cites W2061609938 @default.
- W2021586444 cites W2068442870 @default.
- W2021586444 cites W2068640368 @default.
- W2021586444 cites W2072797273 @default.
- W2021586444 cites W2078590536 @default.
- W2021586444 cites W2079711588 @default.
- W2021586444 cites W2081318971 @default.
- W2021586444 cites W2082321620 @default.
- W2021586444 cites W2082848755 @default.
- W2021586444 cites W2085767500 @default.
- W2021586444 cites W2092232077 @default.
- W2021586444 cites W2102605158 @default.
- W2021586444 cites W2103722820 @default.
- W2021586444 cites W2117985944 @default.
- W2021586444 cites W2121496050 @default.
- W2021586444 cites W2122180971 @default.
- W2021586444 cites W2128920830 @default.
- W2021586444 cites W2131226177 @default.
- W2021586444 cites W2131601262 @default.
- W2021586444 cites W2137411554 @default.
- W2021586444 cites W2154945214 @default.
- W2021586444 cites W2166224995 @default.
- W2021586444 cites W2167941163 @default.
- W2021586444 cites W2488433791 @default.
- W2021586444 doi "https://doi.org/10.1002/jbm.a.33048" @default.
- W2021586444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21442723" @default.
- W2021586444 hasPublicationYear "2011" @default.
- W2021586444 type Work @default.
- W2021586444 sameAs 2021586444 @default.
- W2021586444 citedByCount "23" @default.
- W2021586444 countsByYear W20215864442012 @default.
- W2021586444 countsByYear W20215864442013 @default.
- W2021586444 countsByYear W20215864442014 @default.
- W2021586444 countsByYear W20215864442015 @default.
- W2021586444 countsByYear W20215864442016 @default.
- W2021586444 countsByYear W20215864442017 @default.
- W2021586444 countsByYear W20215864442018 @default.
- W2021586444 countsByYear W20215864442019 @default.
- W2021586444 countsByYear W20215864442020 @default.
- W2021586444 countsByYear W20215864442021 @default.
- W2021586444 countsByYear W20215864442022 @default.
- W2021586444 countsByYear W20215864442023 @default.
- W2021586444 crossrefType "journal-article" @default.
- W2021586444 hasAuthorship W2021586444A5017735982 @default.
- W2021586444 hasAuthorship W2021586444A5025687324 @default.
- W2021586444 hasAuthorship W2021586444A5031487758 @default.
- W2021586444 hasAuthorship W2021586444A5037434090 @default.
- W2021586444 hasAuthorship W2021586444A5051906887 @default.
- W2021586444 hasAuthorship W2021586444A5071144290 @default.
- W2021586444 hasAuthorship W2021586444A5073473654 @default.
- W2021586444 hasAuthorship W2021586444A5091404674 @default.
- W2021586444 hasConcept C108586683 @default.
- W2021586444 hasConcept C12554922 @default.
- W2021586444 hasConcept C136229726 @default.
- W2021586444 hasConcept C150903083 @default.
- W2021586444 hasConcept C153400128 @default.
- W2021586444 hasConcept C15920480 @default.
- W2021586444 hasConcept C159985019 @default.
- W2021586444 hasConcept C171250308 @default.
- W2021586444 hasConcept C188027245 @default.