FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021591676> ?p ?o ?g. }

• W2021591676 endingPage "738" @default.
• W2021591676 startingPage "732" @default.
• W2021591676 abstract "The expression of peroxisome proliferator-activated receptor (PPAR)gamma in thyroid neoplasias and in normal thyroid (NT) tissues has not been fully investigated. The objectives of the present work were: to study and compare the relative expression of PPARgamma in normal, benign and malignant thyroid tissues and to correlate PPARgamma immunostaining with clinical/pathological features of patients with thyroid cancer. We analysed the expression of PPARgamma in several types of thyroid tissues by reverse transcription-polymerase chain reaction (RT-PCR), interphase fluorescent in situ hybridisation, real-time RT-PCR and immunohistochemistry. We have demonstrated that NT tissues express PPARgamma both at mRNA and at protein level. PAX8-PPARgamma fusion gene expression was found in 25% (six of 24) of follicular thyroid carcinomas (FTCs) and in 17% (six of 36) of follicular thyroid adenomas, but in none of the 10 normal tissues, 28 nodular hyperplasias, 38 papillary thyroid carcinomas (PTCs) and 11 poorly differentiated thyroid carcinomas (PDTCs). By real-time RT-PCR, we observed that tumours negative for the PAX8-PPARgamma rearrangement expressed lower levels of PPARgamma mRNA than the NT. Overexpression of PPARgamma transcripts was detected in 80% (four of five) of translocation-positive tumours. Diffuse nuclear staining was significantly (P<0.05) less prevalent in FTCs (53%; 18 of 34), PTCs (49%; 19 of 39) and PDTCs (0%; zero of 13) than in normal tissue (77%; 36 of 47). Peroxisome proliferator-activated receptorgamma-negative FTCs were more likely to be locally invasive, to persist after surgery, to metastasise and to have poorly differentiated areas. Papillary thyroid carcinomas with a predominantly follicular pattern were more often PPARgamma negative than classic PTCs (80% vs 28%; P=0.01). Our results demonstrated that PPARgamma is underexpressed in translocation-negative thyroid tumours of follicular origin and that a further reduction of PPARgamma expression is associated with dedifferentiation at later stages of tumour development and progression." @default.
• W2021591676 created "2016-06-24" @default.
• W2021591676 creator A5024166264 @default.
• W2021591676 creator A5059384540 @default.
• W2021591676 creator A5063899869 @default.
• W2021591676 creator A5083511684 @default.
• W2021591676 creator A5085444443 @default.
• W2021591676 creator A5088152017 @default.
• W2021591676 creator A5090206042 @default.
• W2021591676 date "2004-07-06" @default.
• W2021591676 modified "2023-10-10" @default.
• W2021591676 title "Underexpression of peroxisome proliferator-activated receptor (PPAR)γ in PAX8/PPARγ-negative thyroid tumours" @default.
• W2021591676 cites W1586597239 @default.
• W2021591676 cites W1670226482 @default.
• W2021591676 cites W1800883185 @default.
• W2021591676 cites W1820449832 @default.
• W2021591676 cites W1925149569 @default.
• W2021591676 cites W1966861485 @default.
• W2021591676 cites W1974407322 @default.
• W2021591676 cites W1975160900 @default.
• W2021591676 cites W1986219421 @default.
• W2021591676 cites W1991050772 @default.
• W2021591676 cites W1993342645 @default.
• W2021591676 cites W2005674716 @default.
• W2021591676 cites W2010637857 @default.
• W2021591676 cites W2013427049 @default.
• W2021591676 cites W2019743685 @default.
• W2021591676 cites W2022048961 @default.
• W2021591676 cites W2031694725 @default.
• W2021591676 cites W2039518748 @default.
• W2021591676 cites W2045833013 @default.
• W2021591676 cites W2046833545 @default.
• W2021591676 cites W2047591801 @default.
• W2021591676 cites W2050352100 @default.
• W2021591676 cites W2050717908 @default.
• W2021591676 cites W2057836926 @default.
• W2021591676 cites W2059964515 @default.
• W2021591676 cites W2061809006 @default.
• W2021591676 cites W2064974844 @default.
• W2021591676 cites W2082597621 @default.
• W2021591676 cites W2087351233 @default.
• W2021591676 cites W2087916660 @default.
• W2021591676 cites W2091321756 @default.
• W2021591676 cites W2097679250 @default.
• W2021591676 cites W2102021118 @default.
• W2021591676 cites W2102998952 @default.
• W2021591676 cites W2141553512 @default.
• W2021591676 cites W2160114980 @default.
• W2021591676 cites W2163244708 @default.
• W2021591676 cites W2164015929 @default.
• W2021591676 cites W2170651583 @default.
• W2021591676 cites W2171518012 @default.
• W2021591676 doi "https://doi.org/10.1038/sj.bjc.6601989" @default.
• W2021591676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2364771" @default.
• W2021591676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15238980" @default.
• W2021591676 hasPublicationYear "2004" @default.
• W2021591676 type Work @default.
• W2021591676 sameAs 2021591676 @default.
• W2021591676 citedByCount "64" @default.
• W2021591676 countsByYear W20215916762012 @default.
• W2021591676 countsByYear W20215916762013 @default.
• W2021591676 countsByYear W20215916762014 @default.
• W2021591676 countsByYear W20215916762015 @default.
• W2021591676 countsByYear W20215916762016 @default.
• W2021591676 countsByYear W20215916762020 @default.
• W2021591676 countsByYear W20215916762021 @default.
• W2021591676 countsByYear W20215916762022 @default.
• W2021591676 countsByYear W20215916762023 @default.
• W2021591676 crossrefType "journal-article" @default.
• W2021591676 hasAuthorship W2021591676A5024166264 @default.
• W2021591676 hasAuthorship W2021591676A5059384540 @default.
• W2021591676 hasAuthorship W2021591676A5063899869 @default.
• W2021591676 hasAuthorship W2021591676A5083511684 @default.
• W2021591676 hasAuthorship W2021591676A5085444443 @default.
• W2021591676 hasAuthorship W2021591676A5088152017 @default.
• W2021591676 hasAuthorship W2021591676A5090206042 @default.
• W2021591676 hasBestOaLocation W20215916761 @default.
• W2021591676 hasConcept C104317684 @default.
• W2021591676 hasConcept C124224327 @default.
• W2021591676 hasConcept C126322002 @default.
• W2021591676 hasConcept C134018914 @default.
• W2021591676 hasConcept C142724271 @default.
• W2021591676 hasConcept C170493617 @default.
• W2021591676 hasConcept C187345961 @default.
• W2021591676 hasConcept C204232928 @default.
• W2021591676 hasConcept C2779761222 @default.
• W2021591676 hasConcept C2993294228 @default.
• W2021591676 hasConcept C4224716 @default.
• W2021591676 hasConcept C526584372 @default.
• W2021591676 hasConcept C55493867 @default.
• W2021591676 hasConcept C71924100 @default.
• W2021591676 hasConcept C86339819 @default.
• W2021591676 hasConcept C86803240 @default.
• W2021591676 hasConceptScore W2021591676C104317684 @default.
• W2021591676 hasConceptScore W2021591676C124224327 @default.
• W2021591676 hasConceptScore W2021591676C126322002 @default.
• W2021591676 hasConceptScore W2021591676C134018914 @default.
• W2021591676 hasConceptScore W2021591676C142724271 @default.

• next