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• W2021608733 abstract "The secreted Frizzled receptor related proteins (Sfrp's) belong to a protein family that comprises antagonists and modifiers of Wnt and BMP signalling. Here we report the isolation and expression pattern of the Sfrp gene Sizzled in the chick. Sizzled genes, as well as the closely related crescent genes, exist in the genomes of fishes, frogs and chicks, but not of mammals. The chicken Sizzled gene (Szl) is initially expressed in the anterior endoderm of gastrulating and early head fold embryos. An additional, separate expression domain develops at the posterior end of the embryo from the head process stage onwards. Szl transcripts are then detected in precardial mesodermal cells, are transiently transcribed in the straight heart tube, and later prominently in the splanchnic mesoderm surrounding the arterial pole of the developing heart, the anterior heart field. These cells are subsequently recruited to form the cardiac outflow tract. cSzl expression is downregulated when the septation of the outflow tract by neural crest derived cells begins." @default.
• W2021608733 created "2016-06-24" @default.
• W2021608733 creator A5064875865 @default.
• W2021608733 creator A5078824209 @default.
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• W2021608733 date "2008-07-01" @default.
• W2021608733 modified "2023-09-26" @default.
• W2021608733 title "Expression of the chick Sizzled gene in progenitors of the cardiac outflow tract" @default.
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• W2021608733 doi "https://doi.org/10.1016/j.gep.2008.02.004" @default.
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