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• W2021609230 abstract "Objective— Sphingomyelin deposition and metabolism occurs in the atherosclerotic plaque, leading to the formation of sphingosine-1-phosphate (S1P), which activates G protein–coupled receptors to regulate vascular and immune cells. The role of S1P receptors in atherosclerosis has not been examined. Methods and Results— We tested the hypothesis that S1P receptor-2 (S1PR2) regulates atherosclerosis. Apoe −/− S1pr2 −/− mice showed greatly attenuated atherosclerosis compared with the Apoe −/− mice. Bone marrow transplant experiments indicate that S1PR2 function in the hematopoietic compartment is critical. S1PR2 is expressed in bone marrow–derived macrophages and in macrophage-like foam cells in atherosclerotic plaques. Reduced macrophage-like foam cells were found in the atherosclerotic plaques of Apoe −/− S1pr2 −/− mice, suggesting that S1PR2 retains macrophages in atherosclerotic plaques. Lipoprotein profiles, plasma lipids, and oxidized low-density lipoprotein uptake by bone marrow–derived macrophages were not altered by the S1pr2 genotype. In contrast, endotoxin-induced inflammatory cytokine (interleukin [IL]-1β, IL-18) levels in the serum of S1PR2 knockout mice were significantly reduced. Furthermore, treatment of wild-type mice with S1PR2 antagonist JTE-013 suppressed IL-1β and IL-18 levels in plasma. Conclusion— These data suggest that S1PR2 signaling in the plaque macrophage regulates macrophage retention and inflammatory cytokine secretion, thereby promoting atherosclerosis." @default.
• W2021609230 created "2016-06-24" @default.
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• W2021609230 date "2011-01-01" @default.
• W2021609230 modified "2023-10-17" @default.
• W2021609230 title "Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis" @default.
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• W2021609230 doi "https://doi.org/10.1161/atvbaha.110.213496" @default.
• W2021609230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3013369" @default.
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