Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021612022> ?p ?o ?g. }
- W2021612022 abstract "G protein coupled receptors (GPCRs) are one of the major classes of cell surface receptors and are associated with a group of G proteins consisting of three subunits termed alpha, beta, and gamma. G proteins are classified into four families according to their α subunit; Gαi, Gαs, Gα12/13, and Gαq. There are several downstream pathways of Gαq of which the best known is upon activation via guanosine triphosphate (GTP), Gαq activates phospholipase Cβ, hydrolyzing phosphatidylinositol 4,5-biphosphate into diacylglycerol and inositol triphosphate and activating protein kinase C and increasing calcium efflux from the endoplasmic reticulum. Although G proteins, in particular, the Gαq/11 are central elements in GPCR signaling, their actual roles have not yet been thoroughly investigated. The lack of research of the role on Gαq/11 in cell biology is partially due to the obscure nature of the available pharmacological agents. YM-254890 is the most useful Gαq-selective inhibitor with antiplatelet, antithrombotic, and thrombolytic effects. YM-254890 inhibits Gαq signaling pathways by preventing the exchange of guanosine diphosphate for GTP. UBO-QIC is a structurally similar compound to YM-254890, which can inhibit platelet aggregation and cause vasorelaxation in rats. Many agents are available for the study of signaling downstream of Gαq/11. The role of G proteins could potentially represent a novel therapeutic target. This review will explore the range of pharmacological and molecular tools available for the study of the role of Gαq/11 in GPCR signaling." @default.
- W2021612022 created "2016-06-24" @default.
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- W2021612022 date "2015-03-24" @default.
- W2021612022 modified "2023-10-17" @default.
- W2021612022 title "Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11" @default.
- W2021612022 cites W1528703967 @default.
- W2021612022 cites W1539145066 @default.
- W2021612022 cites W1551542801 @default.
- W2021612022 cites W1592231190 @default.
- W2021612022 cites W1657825487 @default.
- W2021612022 cites W1763096406 @default.
- W2021612022 cites W1792137123 @default.
- W2021612022 cites W1861134585 @default.
- W2021612022 cites W1863023627 @default.
- W2021612022 cites W1881316487 @default.
- W2021612022 cites W1963842041 @default.
- W2021612022 cites W1967031212 @default.
- W2021612022 cites W1967127487 @default.
- W2021612022 cites W1967767166 @default.
- W2021612022 cites W1967773993 @default.
- W2021612022 cites W1968817307 @default.
- W2021612022 cites W1969713529 @default.
- W2021612022 cites W1974452657 @default.
- W2021612022 cites W1974781424 @default.
- W2021612022 cites W1981493299 @default.
- W2021612022 cites W1984247884 @default.
- W2021612022 cites W1987354436 @default.
- W2021612022 cites W1988734678 @default.
- W2021612022 cites W1993468618 @default.
- W2021612022 cites W2001379640 @default.
- W2021612022 cites W2004218824 @default.
- W2021612022 cites W2004871593 @default.
- W2021612022 cites W2006145911 @default.
- W2021612022 cites W2006247873 @default.
- W2021612022 cites W2007133641 @default.
- W2021612022 cites W2008052643 @default.
- W2021612022 cites W2008635838 @default.
- W2021612022 cites W2013771801 @default.
- W2021612022 cites W2013997965 @default.
- W2021612022 cites W2015588801 @default.
- W2021612022 cites W2017294957 @default.
- W2021612022 cites W2017316435 @default.
- W2021612022 cites W2019832656 @default.
- W2021612022 cites W2023661909 @default.
- W2021612022 cites W2033138433 @default.
- W2021612022 cites W2036616880 @default.
- W2021612022 cites W2036842366 @default.
- W2021612022 cites W2040152909 @default.
- W2021612022 cites W2044775506 @default.
- W2021612022 cites W2045254177 @default.
- W2021612022 cites W2049103849 @default.
- W2021612022 cites W2050307742 @default.
- W2021612022 cites W2054904385 @default.
- W2021612022 cites W2055293344 @default.
- W2021612022 cites W2055571119 @default.
- W2021612022 cites W2058400088 @default.
- W2021612022 cites W2063318692 @default.
- W2021612022 cites W2065089586 @default.
- W2021612022 cites W2065869146 @default.
- W2021612022 cites W2066175322 @default.
- W2021612022 cites W2069405208 @default.
- W2021612022 cites W2070288681 @default.
- W2021612022 cites W2070382741 @default.
- W2021612022 cites W2074844667 @default.
- W2021612022 cites W2078859234 @default.
- W2021612022 cites W2079104124 @default.
- W2021612022 cites W2080229909 @default.
- W2021612022 cites W2080413833 @default.
- W2021612022 cites W2082995557 @default.
- W2021612022 cites W2085046266 @default.
- W2021612022 cites W2086853522 @default.
- W2021612022 cites W2088823687 @default.
- W2021612022 cites W2090366817 @default.
- W2021612022 cites W2098372009 @default.
- W2021612022 cites W2100554784 @default.
- W2021612022 cites W2101413460 @default.
- W2021612022 cites W2109014958 @default.
- W2021612022 cites W2112072577 @default.
- W2021612022 cites W2112677891 @default.
- W2021612022 cites W2114792426 @default.
- W2021612022 cites W2120071061 @default.
- W2021612022 cites W2120297430 @default.
- W2021612022 cites W2123276348 @default.
- W2021612022 cites W2124062297 @default.
- W2021612022 cites W2126595561 @default.
- W2021612022 cites W2133570574 @default.
- W2021612022 cites W2139923235 @default.
- W2021612022 cites W2144844901 @default.
- W2021612022 cites W2149104897 @default.
- W2021612022 cites W2153283433 @default.
- W2021612022 cites W2156103849 @default.