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• W2021621355 abstract "Three new diterpenoids including two pimaranes (1 and 2) and a labdane (3) were isolated from the whole herb of Plectranthus ernstii. The structures of these compounds were determined as rel-15(ζ),16-epoxy-7α-hydroxypimar-8,14-ene (1) and rel-15(ζ),16-epoxy-7-oxopimar-8,14-ene (2), and compound 3 was elucidated as 1R,11S-dihydroxy-8R,13R-epoxylabd-14-ene on the basis of single-crystal X-ray structural analysis. Compound 1 exhibited moderate antistaphylococcal activity against a range of multidrug-resistant (MDR) and methicillin-resistant (MRSA) strains of Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 32 μg/mL. All three diterpenes exhibited antimycobacterial activity against three strains of rapidly growing mycobacteria with MIC values ranging from 8 to 128 μg/mL." @default.
• W2021621355 created "2016-06-24" @default.
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• W2021621355 date "2009-05-15" @default.
• W2021621355 modified "2023-10-12" @default.
• W2021621355 title "Antibacterial Diterpenes from <i>Plectranthus ernstii</i>" @default.
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• W2021621355 doi "https://doi.org/10.1021/np800581s" @default.
• W2021621355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19445517" @default.
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