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- W2021623930 abstract "Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin-β cyclodextrin dispersions were prepared with a view to study the influence of β-CD on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of β-CD as carrier by Physical mixture, solvent evaporation method, Kneading method and Fusion Method. They were evaluated for drug content, moisture content, FTIR spectral studies, solubility, in-vitro dissolution and release kinetics. The solubility profile indicated that there is increase in solubility of Simvastatin when β-CD concentration is increased. The solid dispersion complex of drug (1:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions (1:1 and 1:3). This in turn can improve the bioavailability. FT-IR shows the complexation and compatibility of rug and carrier." @default.
- W2021623930 created "2016-06-24" @default.
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- W2021623930 date "2011-10-11" @default.
- W2021623930 modified "2023-09-25" @default.
- W2021623930 title "EVALUATION OF SOLUBILITY OF SIMVASTATIN USING β-CYCLODEXTRIN BY SOLID DISPERSION TECHNIQUE" @default.
- W2021623930 doi "https://doi.org/10.7439/ijbr.v1i2.58" @default.
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