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• W2021633435 abstract "Objective : Presently, there is no reliable method that allows accurate prediction of the clinical course of an individual superficial bladder tumour. As 10-20% of superficial bladder tumours will become invasive, the discovery of a single or combination of prognostic markers would allow the early establishment of appropriate treatment regimens that could potentially prolong patient life. The aim of this study was to evaluate the potential of both p27 and epidermal growth factor receptor (EGFR), individually and in combination as prognostic markers for bladder cancer. Patients and methods : Immunohistochemistry was used to assess bladder tumours for p27 (54 samples), nuclear EGFR (65 samples) and 49 biopsies for both markers. Results : To assess p27 expression, a cut-off value of 30% was employed. Associations were found between p27 status and grade, stage, disease recurrence and progression ( p =0.0113, 0.0001, 0.0167 and 0.0024, respectively). Patients presenting with p27 positive tumours had longer disease-free and progression-free survival, compared to p27 negative patients. Through multivariate analysis, p27 was found to be both an independent marker of both recurrence and disease progression ( p =0.0272 and 0.0140, respectively). To assess nuclear EGFR expression, a cut-off value of 5% was employed. Associations were found between nuclear EGFR expression and disease progression ( p =0.0021) and progression-free survival (log-rank analysis: p =0.0117 ). However, when p27 and nuclear EGFR expression were combined this provided a superior prognostic indicator than either p27 or nuclear EGFR expression alone (univariate p =0.0013, multivariate: p =0.008 ). Conclusions : Individually, both p27 and EGFR are excellent predictors of disease progression in bladder cancer patients, however when both markers are combined a superior prognostic marker is created. In the future combined p27/EGFR staining may lead to the implementation of earlier and more aggressive treatment for patients with a poor prognosis, leading to an improved control of tumours." @default.
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• W2021633435 date "2002-01-01" @default.
• W2021633435 modified "2023-10-17" @default.
• W2021633435 title "Prognostic Role of P27 kip1 and Epidermal Growth Factor Receptor in Transitional Cell Carcinoma of the Bladder" @default.
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• W2021633435 doi "https://doi.org/10.1080/15610950290026536" @default.
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