FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021637911> ?p ?o ?g. }

• W2021637911 endingPage "332" @default.
• W2021637911 startingPage "322" @default.
• W2021637911 abstract "The effect of four polymorphic genes of folate-dependent methionine biosynthesis have been investigated in mothers affected by a neural tube defect pregnancy (NTD) and matched controls. The influence of the various genotypes on total red cell 5-methyl-H(4)folate,5,10-methenyl-H(4)folate, and 5-formyl-H(4)folate is reported, as is the effect on homocysteine and radioassay folate in both serum and red cells. All of the single nucleotide polymorphisms studied would seem to contribute to the cellular folate profile in some way. From the data presented, and from the work of others, it is likely that C677T 5,10-methylenetetrahydrofolate reductase is the most important of these polymorphisms. Control mother folate profiles seem reasonably predictive of any given methionine cycle mutation, but profiles in NTD mothers do not. On this basis, it seems likely that some other, as yet unidentified folate lesion is causal for NTD. In NTD-C677T 5,10-methylenetetrahydrofolate reductase in particular, indexes of folate depletion such as high-performance liquid chromatography (HPLC) folate level, oligo-gamma-glutamyl chain length, homocysteine, and radioassay folate values all seem to deteriorate with increased mutant allele carriage. This indicates that this folate polymorphism may provide a critical threshold effect that helps to promote NTD occurrence in the presence of another, as yet unidentified folate-related factor. In more general terms, on a by genotype basis, all 11 genotypes studied give NTD mothers a higher homocysteine compared to controls. Furthermore, a trend that is less universal indicates that NTD mothers have higher 5,10-methenyl-H(4)folate and 5-methyl-H(4)folate levels and lower 5-formyl-H(4)folate and H(4)PteGlu(1) levels than do controls. One of the most consistent, and possibly specific, differences between participant groups is a statistically significant elevation of 5,10-methenyl-H(4)folate in NTD mothers (affects three genotypes). Possible interpretations of this finding are discussed." @default.
• W2021637911 created "2016-06-24" @default.
• W2021637911 creator A5040559258 @default.
• W2021637911 creator A5044028650 @default.
• W2021637911 creator A5057001026 @default.
• W2021637911 creator A5082664270 @default.
• W2021637911 date "2001-08-01" @default.
• W2021637911 modified "2023-10-18" @default.
• W2021637911 title "An Examination of Polymorphic Genes and Folate Metabolism in Mothers Affected by a Spina Bifida Pregnancy" @default.
• W2021637911 cites W1886309745 @default.
• W2021637911 cites W1983419413 @default.
• W2021637911 cites W1986667412 @default.
• W2021637911 cites W1987315246 @default.
• W2021637911 cites W1996039085 @default.
• W2021637911 cites W2006833102 @default.
• W2021637911 cites W2007771025 @default.
• W2021637911 cites W2010098219 @default.
• W2021637911 cites W2010563337 @default.
• W2021637911 cites W2015800930 @default.
• W2021637911 cites W2023855717 @default.
• W2021637911 cites W2031262735 @default.
• W2021637911 cites W2039375931 @default.
• W2021637911 cites W2039569970 @default.
• W2021637911 cites W2049439467 @default.
• W2021637911 cites W2056914276 @default.
• W2021637911 cites W2103085707 @default.
• W2021637911 cites W2123554519 @default.
• W2021637911 cites W2144062723 @default.
• W2021637911 cites W2160444453 @default.
• W2021637911 cites W2165715420 @default.
• W2021637911 cites W2325417132 @default.
• W2021637911 cites W349978335 @default.
• W2021637911 cites W4237533794 @default.
• W2021637911 doi "https://doi.org/10.1006/mgme.2001.3205" @default.
• W2021637911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11509014" @default.
• W2021637911 hasPublicationYear "2001" @default.
• W2021637911 type Work @default.
• W2021637911 sameAs 2021637911 @default.
• W2021637911 citedByCount "31" @default.
• W2021637911 countsByYear W20216379112012 @default.
• W2021637911 countsByYear W20216379112013 @default.
• W2021637911 countsByYear W20216379112014 @default.
• W2021637911 countsByYear W20216379112018 @default.
• W2021637911 countsByYear W20216379112021 @default.
• W2021637911 crossrefType "journal-article" @default.
• W2021637911 hasAuthorship W2021637911A5040559258 @default.
• W2021637911 hasAuthorship W2021637911A5044028650 @default.
• W2021637911 hasAuthorship W2021637911A5057001026 @default.
• W2021637911 hasAuthorship W2021637911A5082664270 @default.
• W2021637911 hasConcept C104317684 @default.
• W2021637911 hasConcept C134651460 @default.
• W2021637911 hasConcept C135763542 @default.
• W2021637911 hasConcept C143065580 @default.
• W2021637911 hasConcept C153209595 @default.
• W2021637911 hasConcept C172680121 @default.
• W2021637911 hasConcept C180754005 @default.
• W2021637911 hasConcept C181199279 @default.
• W2021637911 hasConcept C2777003008 @default.
• W2021637911 hasConcept C2777090595 @default.
• W2021637911 hasConcept C2778478650 @default.
• W2021637911 hasConcept C2779234561 @default.
• W2021637911 hasConcept C2780912031 @default.
• W2021637911 hasConcept C43563269 @default.
• W2021637911 hasConcept C515207424 @default.
• W2021637911 hasConcept C54355233 @default.
• W2021637911 hasConcept C55493867 @default.
• W2021637911 hasConcept C80315684 @default.
• W2021637911 hasConcept C86803240 @default.
• W2021637911 hasConceptScore W2021637911C104317684 @default.
• W2021637911 hasConceptScore W2021637911C134651460 @default.
• W2021637911 hasConceptScore W2021637911C135763542 @default.
• W2021637911 hasConceptScore W2021637911C143065580 @default.
• W2021637911 hasConceptScore W2021637911C153209595 @default.
• W2021637911 hasConceptScore W2021637911C172680121 @default.
• W2021637911 hasConceptScore W2021637911C180754005 @default.
• W2021637911 hasConceptScore W2021637911C181199279 @default.
• W2021637911 hasConceptScore W2021637911C2777003008 @default.
• W2021637911 hasConceptScore W2021637911C2777090595 @default.
• W2021637911 hasConceptScore W2021637911C2778478650 @default.
• W2021637911 hasConceptScore W2021637911C2779234561 @default.
• W2021637911 hasConceptScore W2021637911C2780912031 @default.
• W2021637911 hasConceptScore W2021637911C43563269 @default.
• W2021637911 hasConceptScore W2021637911C515207424 @default.
• W2021637911 hasConceptScore W2021637911C54355233 @default.
• W2021637911 hasConceptScore W2021637911C55493867 @default.
• W2021637911 hasConceptScore W2021637911C80315684 @default.
• W2021637911 hasConceptScore W2021637911C86803240 @default.
• W2021637911 hasIssue "4" @default.
• W2021637911 hasLocation W20216379111 @default.
• W2021637911 hasLocation W20216379112 @default.
• W2021637911 hasOpenAccess W2021637911 @default.
• W2021637911 hasPrimaryLocation W20216379111 @default.
• W2021637911 hasRelatedWork W1802058565 @default.
• W2021637911 hasRelatedWork W1827231142 @default.
• W2021637911 hasRelatedWork W2003614689 @default.
• W2021637911 hasRelatedWork W2013161968 @default.
• W2021637911 hasRelatedWork W2021637911 @default.
• W2021637911 hasRelatedWork W2049439467 @default.

• next