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• W2021638104 abstract "Abstract Morphine and other opiates interact powerfully with prostaglandin mechanisms. One interaction is to inhibit the stimulation by E prostaglandins of cyclic AMP formation in rat brain homogenate. This action is stereospecific and is reversed by the specific morphine antagonist, naloxone. Scrutiny of the experimental findings in relation to existing knowledge of opiates, prostaglandins and cyclic AMP leads us to propose that morphine exerts its analgesic and allied effects by inhibiting the stimulation by endogenous E prostaglandin of a PGE-sensitive adenyl cyclase of appropriate neurones." @default.
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• W2021638104 date "1974-09-01" @default.
• W2021638104 modified "2023-09-24" @default.
• W2021638104 title "Hypothesis inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia" @default.
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• W2021638104 doi "https://doi.org/10.1016/0090-6980(74)90100-2" @default.
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