FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021640695> ?p ?o ?g. }

• W2021640695 endingPage "114" @default.
• W2021640695 startingPage "99" @default.
• W2021640695 abstract "Elucidating the altered physiology of various chloroquine resistant (CQR) strains of Plasmodium falciparum is essential for understanding the molecular basis of CQR. In this study, we have devised several new methods for analyzing digestive vacuolar (DV) pH for individual intraerythrocytic parasites under continuous perfusion. These use controlled illumination power and novel data acquisition software, and are based on either acridine orange (AO) emission spectra or ratiometric 5-(and 6-)carboxy-2',7'-dimethyl-3'-hydroxy-6'-N-ethylaminospiro [isobenzofuran-1(3H),9'-(9H)xanthen]-3-one (DM NERF) excitation. Results show that DV pH is more acidic for laboratory strains of CQR parasites relative to chloroquine sensitive (CQS). Using mutant pfcrt allelic exchange clones not previously exposed to chloroquine (CQ), we now show a direct association between acid DV pH, CQ resistance and mutation of pfcrt to either South American (7G8) or South East Asian (Dd2) CQR-associated alleles. Surprisingly, these alleles confer a similar degree of DV acidification. Verapamil (VPL) reversed acid DV pH for the Dd2 mutant C3(Dd2) clone, in a surprisingly rapid fashion, but did not reverse acid DV pH for the 7G8 mutant C6(7G8) clone. Thus, there is a direct link between expression of two major CQR-associated pfcrt alleles and altered parasite DV physiology. The data also support models that envision direct but allele-specific interaction between PfCRT and VPL." @default.
• W2021640695 created "2016-06-24" @default.
• W2021640695 creator A5022780309 @default.
• W2021640695 creator A5043223792 @default.
• W2021640695 creator A5047681833 @default.
• W2021640695 creator A5071314941 @default.
• W2021640695 creator A5075341313 @default.
• W2021640695 creator A5078741265 @default.
• W2021640695 creator A5091520192 @default.
• W2021640695 date "2004-01-01" @default.
• W2021640695 modified "2023-09-26" @default.
• W2021640695 title "Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH" @default.
• W2021640695 cites W1005258775 @default.
• W2021640695 cites W1965288199 @default.
• W2021640695 cites W1968634061 @default.
• W2021640695 cites W1972177048 @default.
• W2021640695 cites W1972440123 @default.
• W2021640695 cites W1973071620 @default.
• W2021640695 cites W1973150223 @default.
• W2021640695 cites W1973771491 @default.
• W2021640695 cites W1976219820 @default.
• W2021640695 cites W1985053924 @default.
• W2021640695 cites W1985860330 @default.
• W2021640695 cites W1985994606 @default.
• W2021640695 cites W1990550339 @default.
• W2021640695 cites W1990721770 @default.
• W2021640695 cites W1992213360 @default.
• W2021640695 cites W1994938895 @default.
• W2021640695 cites W1997935520 @default.
• W2021640695 cites W2001436365 @default.
• W2021640695 cites W2002412788 @default.
• W2021640695 cites W2010989699 @default.
• W2021640695 cites W2018213295 @default.
• W2021640695 cites W2018969086 @default.
• W2021640695 cites W2020251171 @default.
• W2021640695 cites W2032160817 @default.
• W2021640695 cites W2037350416 @default.
• W2021640695 cites W2050052884 @default.
• W2021640695 cites W2050354457 @default.
• W2021640695 cites W2055527040 @default.
• W2021640695 cites W2061431182 @default.
• W2021640695 cites W2067408917 @default.
• W2021640695 cites W2074834150 @default.
• W2021640695 cites W2076833660 @default.
• W2021640695 cites W2078607899 @default.
• W2021640695 cites W2088392937 @default.
• W2021640695 cites W2088804468 @default.
• W2021640695 cites W2090913849 @default.
• W2021640695 cites W2091878349 @default.
• W2021640695 cites W2103526907 @default.
• W2021640695 cites W2104987179 @default.
• W2021640695 cites W2108545589 @default.
• W2021640695 cites W2124397518 @default.
• W2021640695 cites W2125154025 @default.
• W2021640695 cites W2132831164 @default.
• W2021640695 cites W2132923209 @default.
• W2021640695 cites W2147975415 @default.
• W2021640695 cites W2321692484 @default.
• W2021640695 doi "https://doi.org/10.1016/j.molbiopara.2003.09.008" @default.
• W2021640695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14668017" @default.
• W2021640695 hasPublicationYear "2004" @default.
• W2021640695 type Work @default.
• W2021640695 sameAs 2021640695 @default.
• W2021640695 citedByCount "124" @default.
• W2021640695 countsByYear W20216406952012 @default.
• W2021640695 countsByYear W20216406952013 @default.
• W2021640695 countsByYear W20216406952014 @default.
• W2021640695 countsByYear W20216406952015 @default.
• W2021640695 countsByYear W20216406952016 @default.
• W2021640695 countsByYear W20216406952017 @default.
• W2021640695 countsByYear W20216406952018 @default.
• W2021640695 countsByYear W20216406952019 @default.
• W2021640695 countsByYear W20216406952020 @default.
• W2021640695 countsByYear W20216406952021 @default.
• W2021640695 countsByYear W20216406952022 @default.
• W2021640695 countsByYear W20216406952023 @default.
• W2021640695 crossrefType "journal-article" @default.
• W2021640695 hasAuthorship W2021640695A5022780309 @default.
• W2021640695 hasAuthorship W2021640695A5043223792 @default.
• W2021640695 hasAuthorship W2021640695A5047681833 @default.
• W2021640695 hasAuthorship W2021640695A5071314941 @default.
• W2021640695 hasAuthorship W2021640695A5075341313 @default.
• W2021640695 hasAuthorship W2021640695A5078741265 @default.
• W2021640695 hasAuthorship W2021640695A5091520192 @default.
• W2021640695 hasConcept C104317684 @default.
• W2021640695 hasConcept C143065580 @default.
• W2021640695 hasConcept C153911025 @default.
• W2021640695 hasConcept C180754005 @default.
• W2021640695 hasConcept C203014093 @default.
• W2021640695 hasConcept C2777425658 @default.
• W2021640695 hasConcept C2778048844 @default.
• W2021640695 hasConcept C2778371730 @default.
• W2021640695 hasConcept C2779102032 @default.
• W2021640695 hasConcept C54355233 @default.
• W2021640695 hasConcept C74864618 @default.
• W2021640695 hasConcept C81089528 @default.
• W2021640695 hasConcept C86803240 @default.
• W2021640695 hasConceptScore W2021640695C104317684 @default.

• next