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- W2021649700 abstract "Skeletal growth factors participate in the formation of the bones and joints during development, as well as bone modelling during growth and bone remodeling in maturity. Bone morphogenetic proteins and their antagonists collaborate during skeletal morphogenesis. These and other growth factors also regulate the differentiation of mesenchymal stem cells into mature osteoblasts, and control the production of bone matrix during bone formation. They also regulate, in complex ways, the turnover of bone initiated by osteoclastic resorption of bone. Factors such as TGFβ, sequestered in the bone matrix, are released during bone resorption and are likely to be important in promoting the synthesis of new replacement bone. An understanding of the biology of agents that are anabolic in bone is enabling pharmaceutical approaches to providing better quality bone in osteoporosis and osteopenia, as well as the repair and regeneration of bone. Particular examples are the increased bone mass that can be achieved by intermittent injection of parathyroid hormone, and the enhanced repair of fracture and regeneration of bone defects that administration of BMP2 or BMP7 enables. Thus, newly available anabolic agents are enabling exciting new treatment paradigms for metabolic bone diseases, such as osteoporosis and for orthopedic procedures such as fracture repair." @default.
- W2021649700 created "2016-06-24" @default.
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- W2021649700 date "2002-08-01" @default.
- W2021649700 modified "2023-09-27" @default.
- W2021649700 title "Skeletal growth factors" @default.
- W2021649700 doi "https://doi.org/10.1046/j.0219-4810.2002.00011_5.x" @default.
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