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- W2021663818 abstract "In this study we demonstrate that iscoms made with different defined fractions of quillaja saponins (fractions A and C) exhibit strikingly different immunomodulatory activities. Fraction A has a potent immunomodulatory activity by enhancing antigen specific proliferation and production of IL-2 and IFN-γ, interestingly, this is not reflected by increased levels of IgG2a. The C-fraction on the other hand strongly enhance antibody production and has the ability to modulate the IgG subclass pattern towards IgG2a, in spite of the fact that C-iscoms induce only low levels of IFN-γ. Iscoms containing both fractions A and C (Iscoprep™703) induced higher serum antibody responses than iscoms made of either of the fractions alone and showed an enhanced ability to modulate the serum subclass pattern towards IgG2a compared to C-iscoms." @default.
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- W2021663818 date "1999-07-16" @default.
- W2021663818 modified "2023-10-16" @default.
- W2021663818 title "Iscoms with different quillaja saponin components differ in their immunomodulating activities" @default.
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- W2021663818 doi "https://doi.org/10.1016/s0264-410x(99)00128-0" @default.
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