FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021667248> ?p ?o ?g. }

• W2021667248 endingPage "845" @default.
• W2021667248 startingPage "835" @default.
• W2021667248 abstract "The present study has been designed to investigate the effect of fasudil (Rho-kinase inhibitor) in hypercholesterolemia- and hypertension-induced endothelial dysfunction. High fat diet (8 weeks) and desoxycortisone acetate (DOCA) (40 mg·kg –1 ) were administered (s.c.) to rats to produce hypercholesterolemia and hypertension (mean arterial blood pressure > 120 mmHg), respectively. Endothelial dysfunction was assessed using isolated aortic ring, electron microscopy of thoracic aorta, and serum concentration of nitrite/nitrate. The expression of mRNA for p22 phox and eNOS was assessed by using RT-PCR. Serum thiobarbituric acid reactive substances concentration and aortic superoxide anion concentration were estimated to assess oxidative stress. Fasudil (30 mg·kg –1 , p.o.) and atorvastatin (30 mg·kg –1 , p.o.) treatments markedly prevented hypercholesterolemia- and hypertension-evoked attenuation of acetylcholine-induced endothelium-dependent relaxation, impairment of vascular endothelial lining, decrease in expression of mRNA for eNOS and serum nitrite/nitrate concentration, and an increase in expression of mRNA for p22 phox , superoxide anion, and serum thiobarbituric acid reactive substances. The ameliorative effect of fasudil was prevented by L-NAME. In conclusion, fasudil-induced inhibition of Rho-kinase may improve hypercholesterolemia- and hypertension-induced endothelial dysfunction." @default.
• W2021667248 created "2016-06-24" @default.
• W2021667248 creator A5028915928 @default.
• W2021667248 creator A5062544588 @default.
• W2021667248 date "2006-09-01" @default.
• W2021667248 modified "2023-09-23" @default.
• W2021667248 title "Effect of fasudil on macrovascular disorder-induced endothelial dysfunction" @default.
• W2021667248 cites W1489696646 @default.
• W2021667248 cites W1607892649 @default.
• W2021667248 cites W1678800844 @default.
• W2021667248 cites W1967344340 @default.
• W2021667248 cites W1983025646 @default.
• W2021667248 cites W1998830072 @default.
• W2021667248 cites W2007880055 @default.
• W2021667248 cites W2023378262 @default.
• W2021667248 cites W2023876763 @default.
• W2021667248 cites W2026181951 @default.
• W2021667248 cites W2027296100 @default.
• W2021667248 cites W2029298730 @default.
• W2021667248 cites W2029533353 @default.
• W2021667248 cites W2033699446 @default.
• W2021667248 cites W2041865338 @default.
• W2021667248 cites W2046222258 @default.
• W2021667248 cites W2053651022 @default.
• W2021667248 cites W2064358616 @default.
• W2021667248 cites W2069915524 @default.
• W2021667248 cites W2078854975 @default.
• W2021667248 cites W2083481797 @default.
• W2021667248 cites W2088945242 @default.
• W2021667248 cites W2095775530 @default.
• W2021667248 cites W2099309899 @default.
• W2021667248 cites W2107771085 @default.
• W2021667248 cites W2107920372 @default.
• W2021667248 cites W2108116605 @default.
• W2021667248 cites W2109063792 @default.
• W2021667248 cites W2112656429 @default.
• W2021667248 cites W2115427263 @default.
• W2021667248 cites W2127708948 @default.
• W2021667248 cites W2132414739 @default.
• W2021667248 cites W2134603143 @default.
• W2021667248 cites W2145243587 @default.
• W2021667248 cites W2145898095 @default.
• W2021667248 cites W2146960356 @default.
• W2021667248 cites W2148626152 @default.
• W2021667248 cites W2160461563 @default.
• W2021667248 cites W2161467739 @default.
• W2021667248 cites W2162668251 @default.
• W2021667248 cites W2166662752 @default.
• W2021667248 cites W2171284332 @default.
• W2021667248 cites W2190249179 @default.
• W2021667248 cites W4294216491 @default.
• W2021667248 doi "https://doi.org/10.1139/y06-036" @default.
• W2021667248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17111028" @default.
• W2021667248 hasPublicationYear "2006" @default.
• W2021667248 type Work @default.
• W2021667248 sameAs 2021667248 @default.
• W2021667248 citedByCount "15" @default.
• W2021667248 countsByYear W20216672482012 @default.
• W2021667248 countsByYear W20216672482013 @default.
• W2021667248 countsByYear W20216672482014 @default.
• W2021667248 countsByYear W20216672482015 @default.
• W2021667248 countsByYear W20216672482019 @default.
• W2021667248 crossrefType "journal-article" @default.
• W2021667248 hasAuthorship W2021667248A5028915928 @default.
• W2021667248 hasAuthorship W2021667248A5062544588 @default.
• W2021667248 hasConcept C126322002 @default.
• W2021667248 hasConcept C134018914 @default.
• W2021667248 hasConcept C181199279 @default.
• W2021667248 hasConcept C184235292 @default.
• W2021667248 hasConcept C185592680 @default.
• W2021667248 hasConcept C201800478 @default.
• W2021667248 hasConcept C2776048814 @default.
• W2021667248 hasConcept C2776151105 @default.
• W2021667248 hasConcept C2777352226 @default.
• W2021667248 hasConcept C2777504301 @default.
• W2021667248 hasConcept C2777622882 @default.
• W2021667248 hasConcept C2777952589 @default.
• W2021667248 hasConcept C2778326061 @default.
• W2021667248 hasConcept C2780189551 @default.
• W2021667248 hasConcept C2780795997 @default.
• W2021667248 hasConcept C2780829032 @default.
• W2021667248 hasConcept C2780972559 @default.
• W2021667248 hasConcept C519581460 @default.
• W2021667248 hasConcept C55493867 @default.
• W2021667248 hasConcept C71924100 @default.
• W2021667248 hasConcept C84393581 @default.
• W2021667248 hasConceptScore W2021667248C126322002 @default.
• W2021667248 hasConceptScore W2021667248C134018914 @default.
• W2021667248 hasConceptScore W2021667248C181199279 @default.
• W2021667248 hasConceptScore W2021667248C184235292 @default.
• W2021667248 hasConceptScore W2021667248C185592680 @default.
• W2021667248 hasConceptScore W2021667248C201800478 @default.
• W2021667248 hasConceptScore W2021667248C2776048814 @default.
• W2021667248 hasConceptScore W2021667248C2776151105 @default.
• W2021667248 hasConceptScore W2021667248C2777352226 @default.
• W2021667248 hasConceptScore W2021667248C2777504301 @default.
• W2021667248 hasConceptScore W2021667248C2777622882 @default.
• W2021667248 hasConceptScore W2021667248C2777952589 @default.

• next