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• W2021679054 endingPage "718" @default.
• W2021679054 startingPage "709" @default.
• W2021679054 abstract "Superoxide overproduction is a prominent mediator of the endothelial dysfunction associated with a range of vascular disorders, acting in a number of complementary ways to inhibit effective endothelial nitric oxide (NO) activity. The ability of superoxide to quench NO is well known, but oxidants derived from superoxide also appear to inhibit dimethylarginine dimethylaminohydrolase (DDAH) and to oxidize tetrahydrobiopterin (THBP). The former effect boosts the level of methylated arginines that act as potent competitive inhibitors of NO synthase, whereas the latter effect decreases the ability of this enzyme to generate NO, while converting it to a form that readily generates superoxide. The adverse impact of DDAH deficiency on NO production can be offset with supplemental arginine. Although supplementation with THBP has the potential to compensate for the rapid oxidative destruction of this compound, and maintaining optimal vitamin C nutrition may protect or restore the endothelial THBP pool to a limited extent, the most practical way to optimize NO synthase acitivity in the context of THBP deficit may be administration of high-dose folic acid. The primary circulating metabolite of folate, 5-methyltetrahydrofolate (5MTHF), is structurally analogous to THBP, and appears to normalize the activity of NO synthase in THBP-depleted endothelial cells, either because it “pinch hits” for the absent THBP, or interacts allosterically with NO synthase in some other way to promote the proper function of this enzyme. This observation may rationalize recent clinical studies showing a favorable effect of oral folic acid (5–10 mg daily) on dysfunctional endothelium, independent of any concurrent modulation of homocysteine levels. A recent study reports that, whereas either arginine or THBP alone have only a modest impact on dysfunctional aortic endothelium derived from hypercholesterolemic mice, the combination of the two produces a complete normalization of endothelial function. In aggregate, these considerations suggest that joint administration of arginine and high-dose folate may represent a fruitful approach to preventing and treating vascular disorders – albeit the underlying overproduction of superoxide should also be addressed by ameliorating relevant vascular risk factors." @default.
• W2021679054 created "2016-06-24" @default.
• W2021679054 creator A5064469464 @default.
• W2021679054 date "2004-01-01" @default.
• W2021679054 modified "2023-09-25" @default.
• W2021679054 title "Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate" @default.
• W2021679054 cites W12629601 @default.
• W2021679054 cites W133994298 @default.
• W2021679054 cites W1530752355 @default.
• W2021679054 cites W156498367 @default.
• W2021679054 cites W1583601846 @default.
• W2021679054 cites W1678102432 @default.
• W2021679054 cites W1780475239 @default.
• W2021679054 cites W1824150501 @default.
• W2021679054 cites W1879535988 @default.
• W2021679054 cites W1886375502 @default.
• W2021679054 cites W1889649839 @default.
• W2021679054 cites W1907758231 @default.
• W2021679054 cites W1963495254 @default.
• W2021679054 cites W1964526269 @default.
• W2021679054 cites W1967966166 @default.
• W2021679054 cites W1969649775 @default.
• W2021679054 cites W1969673149 @default.
• W2021679054 cites W1970798352 @default.
• W2021679054 cites W1970904231 @default.
• W2021679054 cites W1971106938 @default.
• W2021679054 cites W1971713336 @default.
• W2021679054 cites W1971900098 @default.
• W2021679054 cites W1975974235 @default.
• W2021679054 cites W1977384496 @default.
• W2021679054 cites W1977605936 @default.
• W2021679054 cites W1977662482 @default.
• W2021679054 cites W1979295479 @default.
• W2021679054 cites W1981268963 @default.
• W2021679054 cites W1981988093 @default.
• W2021679054 cites W1984155998 @default.
• W2021679054 cites W1986437440 @default.
• W2021679054 cites W1987937238 @default.
• W2021679054 cites W1988349073 @default.
• W2021679054 cites W1989924068 @default.
• W2021679054 cites W1993469433 @default.
• W2021679054 cites W1993953283 @default.
• W2021679054 cites W2004398529 @default.
• W2021679054 cites W2004648485 @default.
• W2021679054 cites W2010402015 @default.
• W2021679054 cites W2010704943 @default.
• W2021679054 cites W2011089437 @default.
• W2021679054 cites W2011249697 @default.
• W2021679054 cites W2015483365 @default.
• W2021679054 cites W2018598048 @default.
• W2021679054 cites W2018784031 @default.
• W2021679054 cites W2020649932 @default.
• W2021679054 cites W2028571889 @default.
• W2021679054 cites W2028671428 @default.
• W2021679054 cites W2033974115 @default.
• W2021679054 cites W2035190863 @default.
• W2021679054 cites W2035199836 @default.
• W2021679054 cites W2035433779 @default.
• W2021679054 cites W2035928271 @default.
• W2021679054 cites W2037550115 @default.
• W2021679054 cites W2038273086 @default.
• W2021679054 cites W2038677911 @default.
• W2021679054 cites W2041865338 @default.
• W2021679054 cites W2044422396 @default.
• W2021679054 cites W2044568120 @default.
• W2021679054 cites W2046907879 @default.
• W2021679054 cites W2046924003 @default.
• W2021679054 cites W2048900216 @default.
• W2021679054 cites W2052388460 @default.
• W2021679054 cites W2053082071 @default.
• W2021679054 cites W2059694609 @default.
• W2021679054 cites W2061742684 @default.
• W2021679054 cites W2064061284 @default.
• W2021679054 cites W2064337776 @default.
• W2021679054 cites W2066722683 @default.
• W2021679054 cites W2068397769 @default.
• W2021679054 cites W2068695727 @default.
• W2021679054 cites W2070013537 @default.
• W2021679054 cites W2074410655 @default.
• W2021679054 cites W2076639542 @default.
• W2021679054 cites W2076680300 @default.
• W2021679054 cites W2077560102 @default.
• W2021679054 cites W2077921057 @default.
• W2021679054 cites W2077941478 @default.
• W2021679054 cites W2084500917 @default.
• W2021679054 cites W2084761240 @default.
• W2021679054 cites W2084935393 @default.
• W2021679054 cites W2084983662 @default.
• W2021679054 cites W2089452505 @default.
• W2021679054 cites W2092509134 @default.
• W2021679054 cites W2093441969 @default.
• W2021679054 cites W2094508354 @default.
• W2021679054 cites W2095508250 @default.
• W2021679054 cites W2096700125 @default.
• W2021679054 cites W2097105426 @default.
• W2021679054 cites W2097679733 @default.
• W2021679054 cites W2097750015 @default.
• W2021679054 cites W2097980836 @default.

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