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• W2021685622 abstract "Glutathione S-transferase (GST) is major cytosolic detoxification enzymes involved in many pathological and physiological processes. In the present study, two classes of GSTs (VpGST-1 and VpGST-2) were cloned from Venerupis philippinarum haemocytes by cDNA library and RACE approaches. Sequence alignments and phylogenetic analysis together supported that they belonged to a new member of sigma and pi classes GSTs protein family, respectively. The expression profiles of these two genes under Vibrio anguillarum challenge were investigated by quantitative RT-PCR. The bacterial challenge could significantly up-regulate the mRNA expression of both VpGST-1 and VpGST-2 with larger amplitude in VpGST-2, and the feedback speed for VpGST-2 was more rapid than that of VpGST-1. The differences in the response to bacterial challenge indicated that they were functional diversity and probably played cooperative roles in mediating the Vibrio challenge in clam." @default.
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• W2021685622 date "2012-01-01" @default.
• W2021685622 modified "2023-10-06" @default.
• W2021685622 title "Two classes of glutathione S-transferase genes with different response profiles to bacterial challenge in Venerupis philippinarum" @default.
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• W2021685622 doi "https://doi.org/10.1016/j.fsi.2011.10.032" @default.
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