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- W2021695858 abstract "Background and Objective: Host responses following the recognition of bacterial lipopolysaccharide can range from acute inflammation to septic shock. The aim of this study was to evaluate the ability of the KSL‐W decapeptide to bind to and block the endotoxic effects of lipopolysaccharide. Material and Methods: An enzyme‐linked immunosorbent assay‐based binding assay using fluorescently labeled KSL‐W to detect adsorbed Escherichia coli O55:B5 lipopolysaccharide was employed. A commercially available recombinant Factor C lipopolysaccharide detection assay, hemagglutination of rabbit erythrocytes as well as E‐selectin expression in human umbilical vein endothelial cells were used to assess the anti‐endotoxic effects after KSL‐W exposure to E. coli lipopolysaccharide as well as to oral lipopolysaccharide samples. Results: Lipopolysaccharide‐binding assays using E. coli O55:B5 lipopolysaccharide revealed both a higher maximal binding range (532–713 μ m) and a half‐maximum binding concentration (70–185 μ m) for the KSL‐W peptide when compared with its analog control. Significant inhibition of E‐selectin expression in human umbilical vein endothelial cells ( p < 0.0001) as well as hemagglutination of rabbit erythrocytes occurred after the interaction of KSL‐W with E. coli lipopolysaccharide. Recombinant Factor C enzyme detection inhibition revealed dose‐dependent inhibition values ranging from 1.0–51.8 μ m, which were dependent upon the type of lipopolysaccharide sample tested. Conclusion: These results demonstrate that for the concentrations tested, the KSL‐W decapeptide was nontoxic to mammalian cells and could bind to and block the host recognition and response towards enteric, as well as oral, lipopolysaccharide samples." @default.
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- W2021695858 date "2008-06-28" @default.
- W2021695858 modified "2023-10-15" @default.
- W2021695858 title "The anti-endotoxic effects of the KSL-W decapeptide on Escherichia coli O55:B5 and various oral lipopolysaccharides" @default.
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- W2021695858 doi "https://doi.org/10.1111/j.1600-0765.2007.01067.x" @default.
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