FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021700522> ?p ?o ?g. }

• W2021700522 endingPage "50961" @default.
• W2021700522 startingPage "50956" @default.
• W2021700522 abstract "Previous work suggests that normal GLUT4 content is sufficient for increases in muscle glucose uptake (MGU) during exercise because GLUT4 overexpression does not increase exercise-stimulated MGU. Instead of glucose transport, glucose phosphorylation is a primary limitation of exercise-stimulated MGU. It was hypothesized that a partial ablation of GLUT4 would not impair exercise-stimulated MGU when glucose phosphorylation capacity is normal but would do so when glucose phosphorylation capacity was increased. Thus, C57BL/6J mice with hexokinase II (HKII) overexpression (HK(Tg)), a GLUT4 partial knock-out (G4(+/-)), or both (HK(Tg) + G4(+/-)) and wild-type (WT) littermates were implanted with carotid artery and jugular vein catheters for sampling and infusions at 4 months of age. After a 7-day recovery, 5-h fasted mice remained sedentary or ran on a treadmill at 0.6 mph for 30 min (n = 9-12 per group) and received a bolus of 2-deoxy[3H]glucose to provide an index of MGU (Rg). Arterial blood glucose and plasma insulin concentrations were similar in WT, G4(+/-), HKTg, and HKTg + G4(+/-) mice. Sedentary Rg values were the same in all genotypes in all muscles studied, confirming that glucose transport is a significant barrier to basal glucose uptake. Gastrocnemius and soleus Rg were greater in exercising compared with sedentary mice in all genotypes. During exercise, G4(+/-) mice had a marked increase in blood glucose that was corrected by the addition of HK II overexpression. Exercise Rg (micromol/100g/min) was not different between WT and G4(+/-) mice in the gastrocnemius (24 +/- 5 versus 21 +/- 2) or the soleus (54 +/- 6 versus 70 +/- 7). In contrast, the enhanced exercise Rg observed in HKTg mice compared with that in WT mice was absent in HKTg + G4(+/-) mice in both the gastrocnemius (39 +/- 7 versus 22 +/- 6) and the soleus (98 +/- 13 versus 65 +/- 13). Thus, glucose transport is not a significant barrier to exercise-stimulated MGU despite a 50% reduction in GLUT4 content when glucose phosphorylation capacity is normal. However, when glucose phosphorylation capacity is increased by HK II overexpression, GLUT4 availability becomes a marked limitation to exercise-stimulated MGU." @default.
• W2021700522 created "2016-06-24" @default.
• W2021700522 creator A5002368934 @default.
• W2021700522 creator A5031811169 @default.
• W2021700522 creator A5039393797 @default.
• W2021700522 creator A5047692137 @default.
• W2021700522 creator A5052094314 @default.
• W2021700522 creator A5055715144 @default.
• W2021700522 creator A5087053102 @default.
• W2021700522 date "2004-12-01" @default.
• W2021700522 modified "2023-10-03" @default.
• W2021700522 title "Control of Exercise-stimulated Muscle Glucose Uptake by GLUT4 Is Dependent on Glucose Phosphorylation Capacity in the Conscious Mouse" @default.
• W2021700522 cites W1553937914 @default.
• W2021700522 cites W1564626456 @default.
• W2021700522 cites W1577481173 @default.
• W2021700522 cites W1579361584 @default.
• W2021700522 cites W1584735053 @default.
• W2021700522 cites W1718629903 @default.
• W2021700522 cites W1773423156 @default.
• W2021700522 cites W1782165729 @default.
• W2021700522 cites W1785444852 @default.
• W2021700522 cites W1900772535 @default.
• W2021700522 cites W1938033115 @default.
• W2021700522 cites W1973446976 @default.
• W2021700522 cites W1975717637 @default.
• W2021700522 cites W1991689145 @default.
• W2021700522 cites W2006997174 @default.
• W2021700522 cites W2022675962 @default.
• W2021700522 cites W2023959345 @default.
• W2021700522 cites W2024190884 @default.
• W2021700522 cites W2027117869 @default.
• W2021700522 cites W2029138831 @default.
• W2021700522 cites W2032227852 @default.
• W2021700522 cites W2043844167 @default.
• W2021700522 cites W2052102985 @default.
• W2021700522 cites W2055718211 @default.
• W2021700522 cites W2057919452 @default.
• W2021700522 cites W2069960997 @default.
• W2021700522 cites W2090730793 @default.
• W2021700522 cites W2099099959 @default.
• W2021700522 cites W2170765517 @default.
• W2021700522 cites W2187136166 @default.
• W2021700522 cites W2302546891 @default.
• W2021700522 cites W4247885211 @default.
• W2021700522 doi "https://doi.org/10.1074/jbc.m408312200" @default.
• W2021700522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15456776" @default.
• W2021700522 hasPublicationYear "2004" @default.
• W2021700522 type Work @default.
• W2021700522 sameAs 2021700522 @default.
• W2021700522 citedByCount "64" @default.
• W2021700522 countsByYear W20217005222012 @default.
• W2021700522 countsByYear W20217005222013 @default.
• W2021700522 countsByYear W20217005222014 @default.
• W2021700522 countsByYear W20217005222015 @default.
• W2021700522 countsByYear W20217005222016 @default.
• W2021700522 countsByYear W20217005222017 @default.
• W2021700522 countsByYear W20217005222018 @default.
• W2021700522 countsByYear W20217005222019 @default.
• W2021700522 countsByYear W20217005222020 @default.
• W2021700522 countsByYear W20217005222021 @default.
• W2021700522 countsByYear W20217005222022 @default.
• W2021700522 crossrefType "journal-article" @default.
• W2021700522 hasAuthorship W2021700522A5002368934 @default.
• W2021700522 hasAuthorship W2021700522A5031811169 @default.
• W2021700522 hasAuthorship W2021700522A5039393797 @default.
• W2021700522 hasAuthorship W2021700522A5047692137 @default.
• W2021700522 hasAuthorship W2021700522A5052094314 @default.
• W2021700522 hasAuthorship W2021700522A5055715144 @default.
• W2021700522 hasAuthorship W2021700522A5087053102 @default.
• W2021700522 hasBestOaLocation W20217005221 @default.
• W2021700522 hasConcept C11960822 @default.
• W2021700522 hasConcept C126322002 @default.
• W2021700522 hasConcept C134018914 @default.
• W2021700522 hasConcept C161573976 @default.
• W2021700522 hasConcept C17093226 @default.
• W2021700522 hasConcept C185592680 @default.
• W2021700522 hasConcept C2776188179 @default.
• W2021700522 hasConcept C2777866211 @default.
• W2021700522 hasConcept C2779306644 @default.
• W2021700522 hasConcept C55493867 @default.
• W2021700522 hasConcept C71924100 @default.
• W2021700522 hasConceptScore W2021700522C11960822 @default.
• W2021700522 hasConceptScore W2021700522C126322002 @default.
• W2021700522 hasConceptScore W2021700522C134018914 @default.
• W2021700522 hasConceptScore W2021700522C161573976 @default.
• W2021700522 hasConceptScore W2021700522C17093226 @default.
• W2021700522 hasConceptScore W2021700522C185592680 @default.
• W2021700522 hasConceptScore W2021700522C2776188179 @default.
• W2021700522 hasConceptScore W2021700522C2777866211 @default.
• W2021700522 hasConceptScore W2021700522C2779306644 @default.
• W2021700522 hasConceptScore W2021700522C55493867 @default.
• W2021700522 hasConceptScore W2021700522C71924100 @default.
• W2021700522 hasIssue "49" @default.
• W2021700522 hasLocation W20217005221 @default.
• W2021700522 hasLocation W20217005222 @default.
• W2021700522 hasOpenAccess W2021700522 @default.
• W2021700522 hasPrimaryLocation W20217005221 @default.
• W2021700522 hasRelatedWork W2004601441 @default.

• next