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• W2021702217 abstract "Background Dermatologists may be called to assist in the diagnosis and management of purpura fulminans. Methods This retrospective case series details the clinical presentation and outcomes of patients presenting with purpura fulminans associated with peripheral gangrene between 1989 and 2004. Results All 12 patients presented with sudden onset of purpuric patches and evolving gangrene of the extremities in association with a shock syndrome (hypotension, oliguria). Eleven patients had disseminated intravascular coagulation. The cause of purpura fulminans was infectious in 9 patients, surgical in two, and cancer in one. Three patients died (25%) within a week of onset of purpura fulminans. Of the 9 surviving patients, 8 required amputation of at least one limb. Four patients required amputation of all 4 limbs. Limitations Retrospective study design, varying clinical descriptions, and potential referral bias are limitations. Conclusion Purpura fulminans in association with symmetric peripheral gangrene is an ominous clinical presentation. Dermatologists may be called to assist in the diagnosis and management of purpura fulminans. This retrospective case series details the clinical presentation and outcomes of patients presenting with purpura fulminans associated with peripheral gangrene between 1989 and 2004. All 12 patients presented with sudden onset of purpuric patches and evolving gangrene of the extremities in association with a shock syndrome (hypotension, oliguria). Eleven patients had disseminated intravascular coagulation. The cause of purpura fulminans was infectious in 9 patients, surgical in two, and cancer in one. Three patients died (25%) within a week of onset of purpura fulminans. Of the 9 surviving patients, 8 required amputation of at least one limb. Four patients required amputation of all 4 limbs. Retrospective study design, varying clinical descriptions, and potential referral bias are limitations. Purpura fulminans in association with symmetric peripheral gangrene is an ominous clinical presentation." @default.
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• W2021702217 date "2007-12-01" @default.
• W2021702217 modified "2023-09-23" @default.
• W2021702217 title "Presentation and outcome of purpura fulminans associated with peripheral gangrene in 12 patients at Mayo Clinic" @default.
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• W2021702217 doi "https://doi.org/10.1016/j.jaad.2007.07.039" @default.
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